FlyBase Allele Report: Hsap\YAP1[UAS.cHa]

General Information

Symbol

Hsap\YAP1^UAS.cHa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Huang

FlyBase ID

FBal0216283

Feature type

allele

Associated gene

Hsap\YAP1

Associated Insertion(s)

Carried in Construct

P{UAS-YAP1.H}

Also Known As

UAS-Yap

Key Links

Transgenic product class

cDNA

(Huang et al., 2005)

wild_type

(Huang et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Huang et al., 2005)

wild_type

(Huang et al., 2005)

Mutagen

in vitro construct

(Huang et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-YAP1.H}

Cytology

Description

UASt regulatory sequences drive expression of a Hsap\YAP1 cDNA.

(Huang et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\YAP1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^GMR.PFa

(Gilbert et al., 2011)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PFa

(Gilbert et al., 2011)

Detailed Description

Statement

Reference

Expression of Hsap\YAP1^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PFa results in eye overgrowth.

(Gilbert et al., 2011)

Expression of Hsap\YAP1^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF does not result in any discernible overgrowth phenotype in the eye.

(Dong et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\YAP1^UAS.cHa, Scer\GAL4^GMR.PFa has abnormal size | adult stage phenotype, enhanceable by mop^sfv3, Scer\GAL4^GMR.PFa

(Gilbert et al., 2011)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Hsap\YAP1^UAS.cHa is a suppressor of lethal | pupal stage phenotype of hpo^GMR.PW, wts^GMR.PT

(Huang et al., 2005)

Hsap\YAP1^UAS.cHa, Scer\GAL4^GMR.PF is a suppressor | partially of lethal phenotype of Scer\GAL4^GMR.PF, hpo^UAS.cWa

(Huang et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\YAP1^UAS.cHa, Scer\GAL4^GMR.PFa has eye phenotype, enhanceable by mop^sfv3

(Gilbert et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

One copy of mop^sfv3 enhances the eye overgrowth phenotype seen when Hsap\YAP1^Scer\UAS.cHa is expressed under the control of Scer\GAL4^GMR.PFa.

(Gilbert et al., 2011)

Co-introduction of wts^GMR.PT and hpo^GMR.PW results in 100% lethality at the early pupal stage. This lethality can be completely rescued by coexpression of Hsap\YAP1^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF.

(Huang et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\YAP1^Scer\UAS.cHa

Hsap\YAP1^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Huang

Secondary FlyBase IDs

References (4)

Report Sections

Open Close