FB2026_02 , released June 18, 2026
Allele: Dmel\AtpαDTS1R2
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General Information
Symbol
Dmel\AtpαDTS1R2
Species
D. melanogaster
Name
FlyBase ID
FBal0152776
Feature type
allele
Associated gene
Dmel\Atpα
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Ashmore et al., 2009)

loss of function allele

(Palladino et al., 2003)
Mutagen
gamma ray
(Palladino et al., 2003)
Progenitor genotype
AtpαDTS2
(Palladino et al., 2003)
Cytology
Description

Atpα protein expression levels are reduced in heterozygotes.

(Ashmore et al., 2009)

AtpαDTS2R1 has a legion that removes part of exon 4, 5 and 6.

(Palladino et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      bang sensitive | dominant

      (Palladino et al., 2003)

      lethal - all die during embryonic stage

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with Atpα01453a)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with Atpα2206)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS1)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS1R1)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2R1)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2R2)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2R3)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαH64)

      (Palladino et al., 2003)

      paralytic | dominant

      (Palladino et al., 2003)

      some die during embryonic stage

      (Palladino et al., 2003)

      some die during embryonic stage (with Atpα01453a)

      (Palladino et al., 2003)

      some die during embryonic stage (with Atpα2206)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS1)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS1R1)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2R1)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2R2)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2R3)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαH64)

      (Palladino et al., 2003)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos cannot form paracellular barriers, show elongated dorsal trunks and show gaps in the ganglionic branches.

      (Ashmore et al., 2009)

      Mutants have tracheal defects, including dorsal trunks that are longer than normal and have diameter defects. Lumens are missing in the ganglionic branches. In contrast to wild type, the barrier function has also been lost in the trachea, allowing a dye to penetrate and accumulate in the tracheal lumen.

      (Paul et al., 2007)

      Unlike wild-type, post stage 15 trachea in AtpαDTS1R2 homozygotes are unable to exclude from their lumens, a fluorescently labelled 10kDa dextran injected into the body cavity. This is consistent with these trachea lacking a functioning septate junction barrier.

      (Paul et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      AtpαDTS1R2 has tracheal dorsal trunk primordium phenotype, suppressible by Scer\GAL4da.G32/Rnor\Atp1a1UAS.GFP

      (Paul et al., 2007)

      AtpαDTS1R2 has septate junction & embryonic tracheal system phenotype, suppressible by Scer\GAL4da.G32/Rnor\Atp1a1UAS.GFP

      (Paul et al., 2007)

      AtpαDTS1R2 has ganglionic tracheal branch primordium phenotype, suppressible by Scer\GAL4da.G32/Rnor\Atp1a1UAS.GFP

      (Paul et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Palladino

      (Paul et al., 2003)

      Revertant.

      (Palladino et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      ATPalphaDTS1R2
      (Ashmore et al., 2009)
      ATPαDTS1R2
      (Khadilkar et al., 2017)
      AtpαDTS1R2
      (Nelson et al., 2010)
      Atpα[DTS1R2]
      (Paul et al., 2007)
      DTS1R2
      (Palladino et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)