FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\scribUAS.cBa
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General Information
Symbol
Dmel\scribUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Bilder
FlyBase ID
FBal0154640
Feature type
allele
Associated gene
Dmel\scrib
Associated Insertion(s)
Carried in Construct
P{UAS-scrib.B}
Also Known As
UAS-scrib
Key Links
Transgenic product class
wild_type
(Pagliarini and Xu, 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Pagliarini and Xu, 2003)
Mutagen
in vitro construct
(Pagliarini and Xu, 2003)
Progenitor genotype
Carried in construct
P{UAS-scrib.B}
Cytology
Description

UAS regulatory sequences drive expression of scrib.

(Pagliarini and Xu, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
scrib
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In larvae in which scribScer\UAS.cBa expression is driven by either Scer\GAL4BG487 or Scer\GAL4C380, the number of active zones is significantly higher than in wild-type boutons. In larvae in which scribScer\UAS.cBa expression is driven by either Scer\GAL4BG487 or Scer\GAL4C380, the density of synaptic vesicles is significantly lower than that observed in wild-type boutons, indicating a gain-of function. Presynaptic expression of transgenic scribScer\UAS.cBa under the regulation of Scer\GAL4C380 results in a significant increase in the number of synaptic active zones compared to wild-type.

      (Roche et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The metastatic behaviour seen in marked clones in the eye disc which are homozygous for scribunspecified and are also expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act5C.PI is suppressed if they are co-expressing scribScer\UAS.cBa.

      (Pagliarini and Xu, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      scribUAS.cBa/Scer\GAL469B rescues scribird15/scrib673

      (Zeitler et al., 2004)

      scribUAS.cBa/Scer\GAL4BG487 rescues scrib1

      (Roche et al., 2002)

      Scer\GAL4futsch-C380/scribUAS.cBa rescues scrib1

      (Roche et al., 2002)

      Scer\GAL4futsch-C380/scribUAS.cBa rescues scrib673

      (Roche et al., 2002)

      scribUAS.cBa/Scer\GAL4BG487 rescues scrib673

      (Roche et al., 2002)
      Fails to rescue

      Scer\GAL4futsch-C380/scribUAS.cBa fails to rescue Df(3R)Tl-X/scrib673

      (Roche et al., 2002)
      Comments

      Expression of scribScer\UAS.cBa under the control of Scer\GAL469B fully rescues the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes.

      (Zeitler et al., 2004)

      In larvae in which scribScer\UAS.cBa expression is driven by either Scer\GAL4BG487 or Scer\GAL4C380, the density of synaptic vesicles is significantly decreased from the levels found in scrib673 mutants. In larvae in which scribScer\UAS.cBa expression is driven by either Scer\GAL4BG487 or Scer\GAL4C380, the number of active zones is significantly higher than in both scrib1 and scrib673 mutants and wild-type boutons. In contrast, the defect in the basal lamina is only partially rescued by transgenic scribScer\UAS.cBa expression. Presynaptic expression of transgenic scribScer\UAS.cBa under the regulation of Scer\GAL4C380 in a scrib673 background rescues the decrease in miniature excitatory junctional currents compared with wild-type. Expression of scribScer\UAS.cBa under the regulation of Scer\GAL4C380 not only rescues the decrease in active zone number found in scrib673 mutants but results in a significant increase in the number of active zones compared to wild-type. Presynaptic expression of transgenic scribScer\UAS.cBa under the regulation of Scer\GAL4C380 in a scrib673/Df(3R)Tl-X background has no effect on the miniature excitatory junctional currents (mEJC), indicating that the reduced mEJC amplitude in scrib673/Df(3R)Tl-X mutants arises from a postsynaptic mechanism.

      (Roche et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      scribScer\UAS.cBa
      scribUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Bilder
      (Pagliarini and Xu, 2003)
      Secondary FlyBase IDs
        References (3)