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General Information
Symbol
Dmel\scribird15
Species
D. melanogaster
Name
FlyBase ID
FBal0127890
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ird15
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cells from scribird15/scrib673 transheterozygous wing discs are round (rather than elongated as in wild type) and have a multilayered organisation (rather than monolayered as in wild type), forming a solid spherical mass rather than the flat disc seen in wild type animals.

scribird15/scrib673 transheterozygous wing discs show a dramatic increase in both the surface area and volume compared to wild type and contain approximately 500% more cells than wild type.

Animals with eyes homozygous for scribird15 never eclose, instead dying as headless pharate adults.

Mutant larvae do not show normal melanisation at a wound site in response to infection. They do not have melanotic tumours.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of scribScer\UAS.cBa under the control of Scer\GAL469B fully rescues the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes.

Expression of scribScer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL469B fully rescues the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes.

Expression of scribΔLRR.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL469B fails to rescue the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes.

Expression of scribL223Q.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL469B fails to rescue the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes.

Expression of scribΔLRR.Scer\UAS.P\T.T:Myr6,T:Avic\GFP under the control of Scer\GAL469B fails to rescue the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes.

Expression of scrib4.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL469B fully rescues the cell polarization phenotype but only partially rescues the disc overgrowth phenotype of scrib673/scribird15 transheterozygotes.

Expression of scribΔPDZs.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL469B fully rescues the cell polarization phenotype but only partially rescues the disc overgrowth phenotype of scrib673/scribird15 transheterozygotes.

Expression of scribΔPDZ3.4.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL469B fully rescues the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes.

Co-expression of scribΔLRR.Scer\UAS.P\T.T:Myr6,T:Avic\GFP and scrib<up>ΔPDZs.Scer\UAS.P\T. T:Avic \GFP</up> under the control of Scer\GAL469B fails to rescue the cell polarization and disc overgrowth phenotypes of scrib673/scribird15 transheterozygotes, even when expression levels are increased via raising larvae at 29 oC.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that fails to induce expression of Ecol\lacZDpt.PR normally in response to infection.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)