FlyBase Allele Report: Dmel\scrib[dt12]

General Information

Symbol

Dmel\scrib^dt12

Species

D. melanogaster

Name

FlyBase ID

FBal0103575

Feature type

allele

Associated gene

Dmel\scrib

Associated Insertion(s)

Carried in Construct

Also Known As

dt12

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Zeitler et al., 2004)

Mutagen

ethyl methanesulfonate

(Zeitler et al., 2004, Kidd et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

epithelial cell (with scrib⁶⁷³)

(Zeitler et al., 2004)

wing disc (with scrib⁶⁷³)

(Zeitler et al., 2004)

Detailed Description

Statement

Reference

Like wild type, cells from scrib^dt12/scrib⁶⁷³ transheterozygous wing discs are arranged in epithelial monolayers and maintain the folded structure of the tissue. However, these scrib^dt12 mutant cells display altered shapes.

scrib^dt12/scrib⁶⁷³ transheterozygous wing discs show an intermediate increase in both the surface area and volume compared to wild type.

(Zeitler et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

scrib⁸⁸²

(Zeitler et al., 2004)

scrib^ird15

(Zeitler et al., 2004)

scrib¹

(Zeitler et al., 2004)

scrib⁶⁷³

(Zeitler et al., 2004)

scrib^dt14

(Zeitler et al., 2004)

scrib⁶⁷³

(Kidd et al., 1999)

scrib^dt14

(Kidd et al., 1999)

scrib^dt6

(Kidd et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

The reason for the early lethality of scrib^dt6/scrib^dt12 and scrib^dt12/Df(3R)Tl-X transheterozygotes is not known but may be because scrib^dt6 and scrib^dt12 were generated on a similar parental chromosome and share an accessory lethal.

(Zeitler et al., 2004)

Comments

Heteroallelic combinations between scrib^dt6, scrib^dt12 and scrib⁸⁸² suggest that scrib^dt6 is the most severe mutation of these three.

(Zeitler et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dt12

(Zeitler et al., 2004, Kidd et al., 1999)

scrib 5

(Zeitler et al., 2004)

scrib^dt12

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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