FlyBase Allele Report: Dmel\dsh[Q108.UAS]

General Information

Symbol

Dmel\dsh^Q108.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0155369

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

P{UAS-dsh.Q108}

Key Links

Transgenic product class

trinucleotide_repeat_expansion

(Marsh et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

trinucleotide_repeat_expansion

(Marsh et al., 2000)

Mutagen

in vitro construct

(Marsh et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-dsh.Q108}

Cytology

Description

UAS regulatory sequences drive expression of dsh in which the endogenous polyglutamine repeat has been replaced by a polyglutamine repeat which encodes 43Q - R - 65Q.

(Marsh et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsh

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Lee et al., 2004)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodegenerative disease

is exacerbated by Hsap\HTT^{N548.Q128.UAS}

(Lee et al., 2004)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die, with Scer\GAL4^elav.PU

(Marsh et al., 2000)

partially lethal - majority die, with Scer\GAL4^hs.2sev

(Marsh et al., 2000)

viable, with Scer\GAL4^dpp.blk1

(Marsh et al., 2000)

visible, with Scer\GAL4^dpp.blk1

(Marsh et al., 2000)

visible, with Scer\GAL4^hs.2sev

(Marsh et al., 2000)

Phenotype Manifest In

eye, with Scer\GAL4^hs.2sev

(Marsh et al., 2000)

wing vein, with Scer\GAL4^dpp.blk1

(Marsh et al., 2000)

wing vein, with Scer\GAL4^hs.2sev

(Marsh et al., 2000)

Detailed Description

Statement

Reference

When dsh^{Q108.Scer\UAS} driven by Scer\GAL4^elav-C155 nuclear aggregates are seen.

(Lee et al., 2004)

Expression of dsh^{Q108.Scer\UAS} under the control of Scer\GAL4^elav.PU results in approximately 20% lethality.

Animals expressing dsh^{Q108.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 have a mild wing vein phenotype.

Expression of dsh^{Q108.Scer\UAS} under the control of Scer\GAL4^hs.2sev results in approximately 70% lethality. Surviving adults have small eyes and extra wing veins.

(Marsh et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dsh^{Q108.Scer\UAS}

dsh^Q108.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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