FB2026_02 , released June 18, 2026
Allele: Dmel\Ubc6EY04634
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General Information
Symbol
Dmel\Ubc6EY04634
Species
D. melanogaster
Name
FlyBase ID
FBal0155722
Feature type
allele
Associated gene
Dmel\Ubc6
Associated Insertion(s)
P{EPgy2}Ubc6EY04634
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Haddad et al., 2013)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}Ubc6EY04634
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  syndromic intellectual disability
      CEA
      (Haddad et al., 2013)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Defects in mitochondrial membrane potential are detected in the neuromuscular junctions of homozygous UbcD6EY04634 mutant third instar larvae.

      UbcD6EY04634 mutant larvae exhibit defects in synaptic vesicle trafficking. The levels of membrane uptake (dye internalisation) in UbcD6EY04634 mutant synaptic boutons in response to nerve stimulation is significantly reduced compared to controls. Synaptic transmission appears normal (both Excitatory Junctional Current (EJC) and miniature Excitatory Junctional Current (mEJC) are similar to controls). No effect is seen on Excitatory Junction Potential (EJP) at low frequencies, but at high frequencies EJP amplitudes in UbcD6EY04634 mutants are steadily reduced, indicating a reduced rate of vesicle replenishment. This reduction in EJP amplitude is less severe when motor neurons are filled with ATP.

      (Haddad et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Ubc6EY04634/Ubc6[+] is a suppressor | partially of chemical sensitive | adult stage phenotype of Otud6C183A

      (Villa et al., 2024)

      Ubc6EY04634/Ubc6[+] is a suppressor | partially of increased mortality | adult stage phenotype of Otud6C183A

      (Villa et al., 2024)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ubc6EY04634 is rescued by Ubc6+tHa

      (Haddad et al., 2013)
      Comments

      Expression of UbcD6+tHa rescues the third instar larval lethality associated with homozygous UbcD6EY04634. The mitochondrial membrane potential and synaptic vesicle trafficking defects seen in UbcD6EY04634 mutant third instar larvae are also rescued, as are the defects in vesicle recycling (reduction in Excitatory Junctional Potential).

      (Haddad et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ubc6EX
      (Villa et al., 2024)
      Ubc6EY04634
      UbcD6EY04634
      (Ribot et al., 2022)
      dRad6EY
      (Haddad et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)