FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ubc6+tHa
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General Information
Symbol
Dmel\Ubc6+tHa
Species
D. melanogaster
Name
FlyBase ID
FBal0288691
Feature type
allele
Associated gene
Dmel\Ubc6
Associated Insertion(s)
Carried in Construct
PBac{Ubc6+tHa}
Key Links
Transgenic product class
genomic_DNA
(Haddad et al., 2013)
wild_type
(Haddad et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Haddad et al., 2013)
wild_type
(Haddad et al., 2013)
Mutagen
in vitro construct
(Haddad et al., 2013)
Progenitor genotype
Carried in construct
PBac{Ubc6+tHa}
Cytology
Description

Genomic UbcD6 (BAC CH322-46G02) has been inserted into the VK37 docking site.

(Haddad et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
Ubc6
Encoded product / tool
Ubc6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Ubc6+tHa rescues Ubc6Δ1

      (Haddad et al., 2013)

      Ubc6+tHa rescues Ubc6EY04634

      (Haddad et al., 2013)
      Comments

      Expression of UbcD6+tHa rescues the lethality associated with homozygous UbcD6Δ1. The mitochondrial membrane potential and synaptic vesicle trafficking defects seen in UbcD6Δ1 mutant third instar larvae are also rescued, as are the defects in vesicle recycling (reduction in Excitatory Junctional Potential).

      Expression of UbcD6+tHa rescues the third instar larval lethality associated with homozygous UbcD6EY04634. The mitochondrial membrane potential and synaptic vesicle trafficking defects seen in UbcD6EY04634 mutant third instar larvae are also rescued, as are the defects in vesicle recycling (reduction in Excitatory Junctional Potential).

      (Haddad et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ubc6+tHa
      UbcD6+tHa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)