FlyBase Allele Report: Dmel\MBD-like[EY04582]

General Information

Symbol

Dmel\MBD-like^EY04582

Species

D. melanogaster

Name

FlyBase ID

FBal0156283

Feature type

allele

Associated gene

Dmel\MBD-like

Associated Insertion(s)

P{EPgy2}MBD-like^EY04582

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}MBD-like^EY04582

Cytology

Description

P{EPgy2} insertion in the 5' coding sequence, 54bp downstream of the initiation codon.

(Marhold et al., 2004)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:9,559,892..9,559,892 [+]

(Gupta et al., 2016, Marhold et al., 2004, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | embryonic stage

(Marhold et al., 2004)

fertile

(Marhold et al., 2004)

suppressor of variegation | dominant, with In(1)w^m4h

(Marhold et al., 2004)

viable

(Marhold et al., 2004)

Phenotype Manifest In

mitotic anaphase & nuclear chromosome

(Marhold et al., 2004)

Detailed Description

Statement

Reference

Approximately 20% of mutant embryos appear smaller and more rounded than controls. 37% of homozygous embryos have chromosome segregation defects, with a high number of chromosome bridges and lagging anaphase chromosomes. Homozygotes have completely normal eyes.

(Marhold et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

MBD-like^EY04582, Mi-2⁴/Mi-2[+] has visible phenotype

(Marhold et al., 2004)

MBD-like^EY04582, Mi-2⁴ has visible phenotype