FlyBase Allele Report: Dmel\InR[A1325D.GMR]

General Information

Symbol

Dmel\InR^A1325D.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0156363

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

P{GMR-InR.A1325D}

Key Links

Transgenic product class

missense_variant

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{GMR-InR.A1325D}

Cytology

Description

GMR regulatory sequences drive expression of a constitutively active form of InR (carries the amino acid replacement A1325D). The mutation mimics the human V938D protein variant of Longo et al., 1992 (PMID:1618747).

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

InR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Tchankouo-Nguetcheu et al., 2014)

Phenotype Manifest In

eye

(Tchankouo-Nguetcheu et al., 2014)

Detailed Description

Statement

Reference

Eyes are slightly larger than wild type.

(Tchankouo-Nguetcheu et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

InR^A1325D.GMR has abnormal size phenotype, enhanceable by Ptp61F[+]/Ptp61F^4-10

(Tchankouo-Nguetcheu et al., 2014)

InR^A1325D.GMR has abnormal size phenotype, enhanceable by Ptp61F^RNAi.UAS.WIZ/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

InR^A1325D.GMR has abnormal size phenotype, enhanceable by Ptp61F^GD3571/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

Suppressed by

Statement

Reference

InR^A1325D.GMR has abnormal size phenotype, suppressible by Ptp61F^UAS.cBa/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

InR^A1325D.GMR has eye phenotype, enhanceable by Ptp61F[+]/Ptp61F^4-10

(Tchankouo-Nguetcheu et al., 2014)

InR^A1325D.GMR has eye phenotype, enhanceable by Ptp61F^RNAi.UAS.WIZ/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

InR^A1325D.GMR has eye phenotype, enhanceable by Ptp61F^GD3571/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

Suppressed by

Statement

Reference

InR^A1325D.GMR has eye phenotype, suppressible by Ptp61F^UAS.cBa/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

8264

w¹¹¹⁸; P{GMR-InR.A1325D}3

8265

w¹¹¹⁸; P{GMR-InR.A1325D}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

InR^A1325D.GMR

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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