FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hr3EY05451
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General Information
Symbol
Dmel\Hr3EY05451
Species
D. melanogaster
Name
FlyBase ID
FBal0156396
Feature type
allele
Associated gene
Dmel\Hr3
Associated Insertion(s)
P{EPgy2}Hr3EY05451
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}Hr3EY05451
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Induction of P{EPgy2}Hr46EY05451 in the developing wing disc under the control of Scer\GAL4ap-md544 does not visibly affect wing development.

      Induction of P{EPgy2}Hr46EY05451 in the developing eye under the control of Scer\GAL4ey.PH does not visibly affect eye development.

      Homozygous Hr46EY05451 and trans-heterozygous Hr46EY05451/Hr46EY10268 mutants are semi-lethal at the larval stage. The few larvae that undergo metamorphosis are delayed and exhibit a significant reduction in body weight. The adult escapers emerge with an approximate 2-day delay, and display female sterility.

      (Montagne et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In combination with S6kScer\UAS.cMa, expression of Hr46EY05451 in the developing wing disc under the control of Scer\GAL4ap-md544 induces a strong enhancement of the S6kScer\UAS.cMa-associated bent-down wing phenotype.

      Ectopic expression of Hr46EY05451, combined with Tsc1Scer\UAS.cTa and gigScer\UAS.cTa, in the developing eye under the control of Scer\GAL4ey.PH, largely counteracts the growth-suppressive effects of Tsc1 and gig.

      Ectopic expression of Hr46EY05451, combined with PtenScer\UAS.cHa, in the developing eye under the control of Scer\GAL4ey.PH, does not counteract the growth-suppressive effects of PtenScer\UAS.cHa expression.

      (Montagne et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference

      In combination with Hsap\RPS6KB1dE.D3E.Scer\UAS, expression of Hr46EY05451 in the developing wing disc under the control of Scer\GAL4ap-md544 induces a strong enhancement of the Hsap\RPS6KB1dE.D3E.Scer\UAS-associated bent-down wing phenotype.

      (Montagne et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hr3EY05451
      Hr46EY05451
      Name Synonyms
      Secondary FlyBase IDs
        References (3)