FlyBase Allele Report: Dmel\HDAC3[B]

General Information

Symbol

Dmel\HDAC3^B

Species

D. melanogaster

Name

FlyBase ID

FBal0156409

Feature type

allele

Associated gene

Dmel\HDAC3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Zhu et al., 2008)

Progenitor genotype

Cytology

Description

Amino acid replacement: V192E.

(Zhu et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:5,473,618..5,473,618 [-]

Nucleotide change:

T5473618A

Amino acid change:

V192E | HDAC3-PA

Reported amino acid change:

V192E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhu et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Zraly et al., 2004)

Phenotype Manifest In

wing

(Zraly et al., 2004)

wing vein | ectopic

(Zraly et al., 2004)

Detailed Description

Statement

Reference

At 29^oC, 32% of heterozygous flies have an ectopic vein emanating from the posterior crossvein of the wing and 68% have wild-type wings.

(Zraly et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

HDAC3^B has visible | dominant phenotype, enhanceable by Snr1^E1/Snr1[+]

(Zraly et al., 2004)

Suppressed by

Statement

Reference

HDAC3^B, Snr1^E1/Snr1[+] has visible | dominant phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

Enhancer of

Statement

Reference

HDAC3^B/Hdac3[+] is an enhancer of visible | dominant phenotype of Snr1^E1

(Zraly et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

HDAC3^B has wing vein | ectopic phenotype, enhanceable by Snr1^E1/Snr1[+]

(Zraly et al., 2004)

HDAC3^B has wing phenotype, enhanceable by Snr1^E1/Snr1[+]

(Zraly et al., 2004)

HDAC3^B has wing vein | ectopic phenotype, enhanceable by Snr1^R3/Snr1[+]

(Zraly et al., 2004)

HDAC3^B has wing phenotype, enhanceable by Snr1^R3/Snr1[+]

(Zraly et al., 2004)

Suppressed by

Statement

Reference

HDAC3^B, Snr1^R3/Snr1[+] has wing vein | ectopic phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC3^B, Snr1^R3/Snr1[+] has wing phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

Enhancer of

Statement

Reference

HDAC3^B/Hdac3[+] is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Zraly et al., 2004)

HDAC3^B/Hdac3[+] is an enhancer of wing phenotype of Snr1^E1

(Zraly et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for Hdac3^B leads to moderate suppression of the eye colour variegation found in In(1)w^m4 mutants.

(Zhu et al., 2008)

At 29^oC, Hdac3^B/Snr1^E1 double heterozygotes have an ectopic wing vein phenotype; 5% have normal wings, 58% have an ectopic vein emanating from the posterior crossvein and 37% have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein.

(Zraly et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

HDAC3^B

Hdac3^B

hdac3^B

(Zhu et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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