FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CortactinM7
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General Information
Symbol
Dmel\CortactinM7
Species
D. melanogaster
Name
FlyBase ID
FBal0156773
Feature type
allele
Associated gene
Dmel\Cortactin
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Somogyi and Rorth, 2004)
Progenitor genotype
P{EPg}CortactinEPg35301
(Somogyi and Rorth, 2004)
Cytology
Description

Imprecise excision has created a 3474bp deletion that removes from 51bp upstream of the insertion site of P{EPg}CortactinEPg35301 to 15bp downstream of the Cortactin gene.

(Somogyi and Rorth, 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show a weak border cell migration defect in the egg chamber.

      Mutant border cells show a slightly reduced rate of uptake of the lipophilic dye FM4-64 compared to wild-type controls.

      (Quinones et al., 2010)

      Homozygous mutants show no visible abnormalities. When mutant ovaries are examined, they exhibit a mild defect in 'dumping' - the transfer of bulk cytoplasmic material from nurse cells to the oocyte. The size of ring canals is seriously reduced in mutant ovaries. Eggs laid by mutant mothers were on average smaller than wild-type. The hatching rate of eggs from mutant mothers is also decreased. With low penetrance (about 6% of stages 5-9 egg chambers) mutants also display discontinuities in the follicular epithelium. Border cell migration is also delayed in mutant ovaries. This remains the case in ovaries with somatically mutant follicle cells but not in germ-line clones.

      (Somogyi and Rorth, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      CortactinM7 has border follicle cell phenotype, suppressible by mimnull

      (Quinones et al., 2010)
      Suppressor of
      Statement
      Reference

      CortactinM7 is a suppressor of border follicle cell phenotype of mimnull

      (Quinones et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mimnull CortactinM7 double mutants have a wild-type border cell migration phenotype in the egg chamber.

      (Quinones et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CortactinM7
      (Zhang et al., 2020, Quinones et al., 2010)
      cortM7
      (Johnson et al., 2008)
      cttnM7
      (Alicea et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)