FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\BubR1DN.UAS
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General Information
Symbol
Dmel\BubR1DN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0157256
Feature type
allele
Associated gene
Dmel\BubR1
Associated Insertion(s)
Carried in Construct
P{UAS-BubR1.DN}
Also Known As
UAS-BubR1DN
Key Links
Transgenic product class
dominant_negative_variant
(Parks, 2004.5.12)
inframe_deletion
(Parks, 2004.5.12)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Parks, 2004.5.12)
inframe_deletion
(Parks, 2004.5.12)
Mutagen
in vitro construct
(Parks, 2004.5.12)
Progenitor genotype
Carried in construct
P{UAS-BubR1.DN}
Cytology
Description

The BubR1 coding sequence truncated at the Stu1 site was cloned into P{Express-UAS}. The C terminal sequence of this dominant negative protein variant should be LEQPFRFPTNFVAKN. Expression is governed by UAS regulatory sequences.

(Parks, 2004.5.12)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
BubR1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN182Q.UAS
      (Park et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      BubR1DN.UAS, Scer\GAL4GMR.PF is a suppressor of visible | adult stage phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Park et al., 2013)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of BubR1DN.Scer\UAS partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF.

      (Park et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Bub1DN.Scer\UAS
      BubR1DN.Scer\UAS
      BubR1DN.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)