FlyBase Allele Report: Dmel\ecd[l(3)23]

General Information

Symbol

Dmel\ecd^l(3)23

Species

D. melanogaster

Name

FlyBase ID

FBal0159268

Feature type

allele

Associated gene

Dmel\ecd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q650term.

(Gaziova et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:2,263,755..2,263,755 [-]

Nucleotide change:

C2263755T

Reported nucleotide change:

C?T

Amino acid change:

Q650term | ecd-PA

Reported amino acid change:

Q650term

(Gaziova et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Gaziova et al., 2004)

abnormal developmental rate (with Df(3L)R-R2)

(Gaziova et al., 2004)

abnormal developmental rate (with ecd²)

(Gaziova et al., 2004)

cell lethal | recessive | somatic clone

(Claudius et al., 2014)

decreased cell number | somatic clone - tissue specific | third instar larval stage

(Erkelenz et al., 2021)

lethal - all die before end of larval stage

(Gaziova et al., 2004)

lethal - all die before end of larval stage (with Df(3L)R-R2)

(Gaziova et al., 2004)

lethal - all die before end of larval stage (with ecd¹)

(Gaziova et al., 2004)

lethal - all die before end of larval stage (with ecd²)

(Gaziova et al., 2004)

some die during larval stage

(Gaziova et al., 2004)

some die during larval stage (with Df(3L)R-R2)

(Gaziova et al., 2004)

some die during larval stage (with ecd¹)

(Gaziova et al., 2004)

some die during larval stage (with ecd²)

(Gaziova et al., 2004)

Phenotype Manifest In

epithelial cell of eye-antennal disc | decreased number | somatic clone - tissue specific | third instar larval stage

(Erkelenz et al., 2021)

eye-antennal disc | somatic clone - tissue specific | third instar larval stage

(Erkelenz et al., 2021)

mouth hook (with ecd¹)

(Gaziova et al., 2004)

Detailed Description

Statement

Reference

In contrast to controls, ecd^l(3)23/ecd^l(3)23 homozygous clones in mosaic third instar larval eye-antennal discs are very rare and very small.

(Erkelenz et al., 2021)

Homozygous clones are not recovered in eye-antennal or wing imaginal discs in third instar larvae.

(Claudius et al., 2014)

ecd^l(3)23/ecd^l(3)23, ecd^l(3)23/Df(3L)R-R2 and ecd²/ecd^l(3)23 animals die after a prolonged L2. Most ecd¹/ecd^l(3)23 animals die during the L2/L3 molt, displaying typical molting defects such as double mouth hooks, but some survive into L3. Larval Lethality in ecd² homozygotes is not rescued by feeding with 20-hydroxyecdysone (50 μg/ml or 250 μg/ml).

(Gaziova et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ecd^l(3)23 has cell lethal | recessive | somatic clone phenotype, suppressible | partially by Ras85D^V12.UAS/Scer\GAL4^Act5C.PI

(Claudius et al., 2014)

ecd^l(3)23 has cell lethal | recessive | somatic clone phenotype, suppressible | partially by Scer\GAL4^Act5C.PI/BacA\p35^UAS.cHa

(Claudius et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Rare and extremely small homozygous ecd^l(3)23 clones can be recovered if cell growth is enhanced in the clones by expression of Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act5C.PI.

(Claudius et al., 2014)

Xenogenetic Interactions

Statement

Reference

Rare and extremely small homozygous ecd^l(3)23 clones can be recovered if cell death is prevented in the clones by expression of BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PI.

(Claudius et al., 2014)

Complementation and Rescue Data

Rescued by

ecd^l(3)23/ecd² is rescued by ecd^+tE5

(Gaziova et al., 2004)

ecd^l(3)23/ecd² is rescued by ecd^+tS4

(Gaziova et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

I. Zhimulev

(Gaziova et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ecd^l(3)23

(Erkelenz et al., 2021, Claudius et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close