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General Information
Symbol
Dmel\Opa1EY09863
Species
D. melanogaster
Name
FlyBase ID
FBal0160917
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
opa1EP, opa1p{EPgy2}CG8479
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{EPgy2}Opa1EY09863
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ERG recordings from Opa1EY09863 homozygous mutant clones in the eye show no off-transient.

Heterozygotes show defects in mitochondrial morphology in the indirect flight muscles, with smaller than normal mitochondria being seen between the muscle fibers.

No effect on mitochondrial network morphology in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster is seen in opa1-likeEY09863/+ animals.

opa1-likeEY09863 mitotic clones in the male germline (i.e. mutant spermatids) exhibit irregularly-shaped nebenkerns, composed of many individual mitochondria that have coalesced beside the nucleus, but have failed to fuse.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

opa1-like[+]/Opa1EY09863 is a suppressor | partially of visible phenotype of park1

opa1-like[+]/Opa1EY09863 is a suppressor of visible phenotype of Pink1B9

NOT Suppressor of
Statement
Reference

opa1-like[+]/Opa1EY09863 is a non-suppressor of flightless phenotype of park1

opa1-like[+]/Opa1EY09863 is a non-suppressor of flightless phenotype of Pink1B9

Phenotype Manifest In
Suppressor of
Statement
Reference

opa1-like[+]/Opa1EY09863 is a suppressor | partially of wing phenotype of park1

opa1-like[+]/Opa1EY09863 is a suppressor | partially of adult thorax phenotype of park1

opa1-like[+]/Opa1EY09863 is a suppressor of wing phenotype of Pink1B9

opa1-like[+]/Opa1EY09863 is a suppressor of adult thorax phenotype of Pink1B9

opa1-like[+]/Opa1EY09863 is a suppressor of mitochondrion & dopaminergic neuron phenotype of Pink1B9

opa1-like[+]/Opa1EY09863 is a suppressor of indirect flight muscle phenotype of Pink1B9

opa1-like[+]/Opa1EY09863 is a suppressor of mitochondrion & indirect flight muscle phenotype of Pink1B9

opa1-like[+]/Opa1EY09863 is a suppressor of mitochondrial inner membrane & indirect flight muscle phenotype of Pink1B9

opa1-like[+]/Opa1EY09863 is a suppressor of mitochondrion & dorso-lateral dopaminergic neuron phenotype of Pink1B9

NOT Suppressor of
Statement
Reference

Opa1[+]/Opa1EY09863 is a non-suppressor of wing phenotype of Scer\GAL4Tub.PU, parkVDRC.cUa

opa1-like[+]/Opa1EY09863 is a non-suppressor of mitochondrion & dorso-lateral dopaminergic neuron phenotype of Pink1UAS.cYa, Scer\GAL4ple.PF/Scer\GAL4ple.PF

Additional Comments
Genetic Interactions
Statement
Reference

The downturned wing and crushed thorax phenotypes but not the flightless phenotype of Pink1B9 mutant flies is significantly suppressed by opa1-likeEY09863/+.

The swollen mitochondria phenotype seen in dopaminergic neurons of Pink1B9 mutants is significantly rescued by opa1-likeEY09863/+.

The abnormal wing posture phenotype and the abnormal morphology of the indirect flight muscles and their mitochondria which is seen in Pink1B9 flies is suppressed by opa1-likeEY09863/+.

The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in Pink1B9 animals is suppressed by opa1-likeEY09863/+.

The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in animals expressing Pink1Scer\UAS.cYa under the control of Scer\GAL4ple.PF is not modified by opa1-likeEY09863/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (10)