FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Efa6c00953
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General Information
Symbol
Dmel\Efa6c00953
Species
D. melanogaster
Name
FlyBase ID
FBal0161813
Feature type
allele
Associated gene
Dmel\Efa6
Associated Insertion(s)
PBac{PB}Efa6c00953
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{PB}Efa6c00953
Cytology
Description
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Gonzalez et al., 2018)
      CEA with Efa6KO1
      (Gonzalez et al., 2018)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  alcohol use disorder
      modeled by RhoGAP18B1
      (Gonzalez et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Efa6c00953 homozygotes and Efa6c00953/Efa6KO1 transheterozygotes are more sensitive (lower survival) to ethanol than Efa6c00953 heterozygotes or wild-type controls, and only develop limited tolerance from previous exposures.

      Naive Efa6c00953/Efa6KO1 mutants show preference for ethanol-laced food, unlike the aversion normally observed in wild-type controls. Efa6c00953/Efa6KO1 mutants previously exposed to ethanol show the same preference for ethanol-laced food as wild-type controls.

      (Gonzalez et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Efa6c00953 has chemical sensitive | adult stage | recessive phenotype, non-enhanceable by Arf6EP2612/Arf6EP2612

      (Gonzalez et al., 2018)
      NOT Enhancer of
      Statement
      Reference

      Efa6c00953/Efa6c00953 is a non-enhancer of chemical sensitive | adult stage | recessive phenotype of Arf6EP2612

      (Gonzalez et al., 2018)
      Suppressor of
      Statement
      Reference

      Efa6[+]/Efa6c00953 is a suppressor of chemical resistant | recessive | adult stage phenotype of RhoGAP18B1

      (Gonzalez et al., 2018)

      Efa6[+]/Efa6c00953 is a suppressor of partially lethal - majority die phenotype of RhoGAP18BNP1514

      (Gonzalez et al., 2018)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      CG31158[+]/Efa6c00953 is an enhancer of ommatidium phenotype of Scer\GAL4GMR.PF, cindrRNAi.PC.PD.UAS

      (Johnson et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ommatidial patterning errors resulting from the expression of cindrdsRNA.PC.PD.Scer\UAS via Scer\GAL4GMR.PF are strongly enhanced in Efa6c00953 heterozygotes.

      (Johnson et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG31158c00953
      Efa6PB
      (Gonzalez et al., 2018)
      Efa6c00953
      Name Synonyms
      Secondary FlyBase IDs
        References (4)