FB2026_02 , released June 18, 2026
Allele: Dmel\stmA18-2
Open Close
General Information
Symbol
Dmel\stmA18-2
Species
D. melanogaster
Name
FlyBase ID
FBal0175429
Feature type
allele
Associated gene
Dmel\stmA
Associated Insertion(s)
Carried in Construct
Also Known As
rbo3
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gamma ray
(Kumar et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q396term.

(Huang et al., 2006, Huang et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,731,170..8,731,170 [-]
Nucleotide change:

C8731170T

Amino acid change:

Q396term | stmA-PA; Q422term | stmA-PB; Q436term | stmA-PC; Q410term | stmA-PD; Q419term | stmA-PE; Q433term | stmA-PF

Reported amino acid change:

Q396term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Huang et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At restrictive temperatures (>37oC), all stmA18-2 mutant animals are completely paralysed within minutes, although control animals appear unaffected. At intermediate temperatures, stmA18-2 mutants show intermediate movement impairment. At 29oC, mutants remain mobile for many hours but become progressively sluggish and die within 1 day. At 33oC, mutants display reduced movement followed by complete paralysis in approximately 30 minutes.

      At permissive temperatures (<25oC), stmA18-2 mutant adult flies appear to act normally and cannot be distinguished from wild-type flies based on locomotion or gross behaviour.

      Heterozygous stmA1/stmA18-2 mutants display 100% paralysis within 3-4 minutes when shifted from room temperature (22oC) to 37oC) and recover with a similar time course after a return to room temperature.

      (Huang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Two second site mutations have been identified in the "rbo[3]" stock. One of these second-site mutations is due to a mutation in Btk29A, and has a phenotype characterized by abnormal morphogenesis of posterior spiracles and lack of tracheal gas-filling at the end of embryogenesis. The other second-site mutation affects the l(2)gl gene, resulting in lethality.

      (Tsikala et al., 2014)
      Comments
      Comments

      Group I allele.

      (Kumar et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      rbo3
      (Tsikala et al., 2014, Huang et al., 2006, Huang et al., 2004)
      stmA18-2
      (Balakrishnan et al., 2018, Kumar et al., 2001)
      stmA18.2
      (Huang et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)