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FB2025_05
,
released December 11, 2025
rbo, cmp44E, rolling blackout, stambhA, stm-A
Please see the JBrowse view of Dmel\stmA for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Gene model reviewed during 6.32
3.4, 2.9 (northern blot)
None of the polypeptides share 100% sequence identity.
794 (aa); 91 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stmA using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
The 2.9kb stmA transcript is detected throughout development and in adults on northern blots.
The 3.4kb stmA transcript is detected in 12-23hr embryos and in adults. It is present at lower abundance than the 2.9kb transcript.
stmA transcripts are ubiquitously distributed in the first half of embryogenesis. They later become more concentrated in the CNS and brain. stmA transcripts are detected in the germline throughout the germarial stages. They are expressed in nurse cells until stage 5 and then are not detected again until stage 9, at which time they are present at high levels. Lower levels are also observed in follicle cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\stmA in JBrowse2-59
2-57.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
stmA is required for both peripheral glutamatergic neuromuscular junction and central cholinergic PSI-DLMn synaptic transmission.
stmA is required at the postdocking stage of synaptic vesicle exocytosis, during vesicle priming, or fusion stages.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
Required for embryonic development and, in conditional mutants, the acute maintenance of coordinated mobility and phototransduction.
Homozygous or heterozygous conditional mutant alleles display slow, temperature sensitive adult paralysis and complete, reversible loss of phototransduction in electroretinogram (ERG) records in the adult eye. Mutants show altered synaptic morphology at the larval neuromuscular junction.
Mutation of stmA causing paralysis also confers veratridine resistance, the two effects are genetically inseparable.
Source for merge of: stmA cmp44E rbo
'stambh' is a Sanskrit word meaning "cessation in general and of locomotion in particular".
