FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eIF4E1S251D
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General Information
Symbol
Dmel\eIF4E1S251D
Species
D. melanogaster
Name
FlyBase ID
FBal0175694
Feature type
allele
Associated gene
Dmel\eIF4E1
Associated Insertion(s)
Carried in Construct
P{eIF4E1S251D}
Key Links
Transgenic product class
missense_variant
(Yan and Macdonald, 2004)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yan and Macdonald, 2004)
Mutagen
in vitro construct
(Yan and Macdonald, 2004)
Progenitor genotype
Carried in construct
P{eIF4E1S251D}
Cytology
Description

Construct: Amino acid replacement: S251D. Encodes a constitutively active form of eIF-4E.

(Yan and Macdonald, 2004)
Allele components
Component
Use(s)
Encoded product / tool
eIF4E1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      eIF4E1S251D is a suppressor of ovary phenotype of bru1QB/bru1PD

      (Yan and Macdonald, 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      aretPD/aretQB eIF-4ES251D ; Lk6EP886/+ females arrest oogenesis at the same stage (stage 9) as aretPD/aretQB ; Lk6EP886/+ females. eIF-4ES251D suppresses the aretPD/aretQB ovary phenotype, delaying arrest of oogenesis until stage 9.

      (Yan and Macdonald, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eIF-4ES251D
      eIF4E1S251D
      Name Synonyms
      Secondary FlyBase IDs
        References (1)