FlyBase Allele Report: Dmel\Su(var)3-7[P9]

General Information

Symbol

Dmel\Su(var)3-7^P9

Species

D. melanogaster

Name

FlyBase ID

FBal0175782

Feature type

allele

Associated gene

Dmel\Su(var)3-7

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Bushey and Locke, 2004)

Progenitor genotype

Cytology

Description

Deletion of nucleotides 2610-2622 (coordinates relative to GenBank accession number X52187.1), resulting in a frameshift at amino acid 742.

(Bushey and Locke, 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:13,267,540..13,267,552 [+]

Comment:

Deletion of nucleotides 2610-2622 (coordinates relative to GenBank accession number X52187.1), resulting in a frameshift.

(Bushey and Locke, 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive | rescuable maternal effect

(Bushey and Locke, 2004)

some die during larval stage | rescuable maternal effect

(Bushey and Locke, 2004)

suppressor of variegation, with In(1)w^m4

(Bushey and Locke, 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous animals derived from homozygous females stop development as first instar larvae (as defined by their mouth hooks). The presence of a Su(var)3-7⁺ chromosome in either the mother or the progeny allows development to proceed to adulthood. Su(var)3-7^P9/Df(3R)Su(var)3-7-P13 animals derived from Su(var)3-7^P9 homozygotes do not develop into adults.

(Bushey and Locke, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

P{P-Sal}Pak3^P-Sal, P{lacW}Dplac, Su(var)3-7^P9 has suppressor of variegation phenotype

(Bushey and Locke, 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

When P{P-Sal}89D is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w^- background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Su(var)3-7^P9. The strong vestigial wing phenotype of vg^21-3/Df(2R)vg-B animals is suppressed by P{P-Sal}89D. This suppression of the phenotype by P{P-Sal}89D is not affected by the presence of Su(var)3-7^P9. Su(var)3-7^P9 suppresses w⁺ silencing caused by P{KP} elements on P{lacW}ci^Dplac. Su(var)3-7^P9 suppresses silencing of P{lacW}ci^Dplac that occurs in P strains such as Harwich and π2.

(Bushey and Locke, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Su(var)3-7^P9 is rescued by Su(var)3-7^+t6.5

(Bushey and Locke, 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Su(var)3-7^P9

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close