Open Close
General Information
Symbol
Dmel\Ced-12dsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0176311
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS sequences drive expression Ced-12 coding sequences (from GenBank:NM135704 nucleotides 123 to 827) repeated in dyad symmetry.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Scer\GAL4slbo.2.6-mediated expression of Ced-12dsRNA.Scer\UAS results in mild defects in border cell migration in which approximately 20% of the border cells fail to migrate completely. Penetrance increases to 40% if two copies of Ced-12dsRNA.Scer\UAS are used.

Scer\GAL4Mef2.PR-mediated expression of Ced-12dsRNA.Scer\UAS does not result in gross defects in the final muscle pattern. However, an approximately 2-fold increase in unfused myoblasts are observed in stage 16 embryos expressing two copies of Ced-12dsRNA.Scer\UAS compared to controls at 29[o]C.

When mbcdsRNA.Scer\UAS is driven by Scer\GAL4pnr-MD237 mutant adults exhibit defects in thorax closure.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Ced-12dsRNA.Scer\UAS under the control of Scer\GAL4Act.PU in the cells surrounding scrib1 clones in the eye-antennal disc significantly suppresses the elimination of the mutant scrib1 clones compared to that seen when the cells surrounding the clone are wild type.

Co-expression of mbcdsRNA.Scer\UAS and Ced-12dsRNA.Scer\UAS using Scer\GAL4slbo.2.6 increases the severity and penetrance of the border cell migration defects compared to when either transgene is expressed alone, such that 55% of the border cells fail to migrate completely.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Ced-12dsRNA.Scer\UAS
Ced-12dsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (4)