FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ncm2a1
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General Information
Symbol
Dmel\ncm2a1
Species
D. melanogaster
Name
FlyBase ID
FBal0176365
Feature type
allele
Associated gene
Dmel\ncm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Coelho et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: E768term.

(Coelho et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:18,446,333..18,446,333 [-]
Nucleotide change:

C18446333T

Amino acid change:

Q768term | ncm-PA

Reported amino acid change:

Q768term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Coelho et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygotes are embryonic lethal. Homozygous clones induced in the wing imaginal disc do not survive. Heterozygotes do not have a Minute bristle phenotype.

      (Coelho et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      ncm[+]/ncm2a1 is an enhancer of visible phenotype of Scer\GAL4Bx-MS1096, aosUAS.cMa

      (Coelho et al., 2005)

      ncm[+]/ncm2a1 is an enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      ncm[+]/ncm2a1 is an enhancer of wing phenotype of Scer\GAL4Bx-MS1096, aosUAS.cMa

      (Coelho et al., 2005)
      NOT Enhancer of
      Statement
      Reference

      ncm[+]/ncm2a1 is a non-enhancer of wing vein phenotype of Scer\GAL4Bx-MS1096, aosUAS.cMa

      (Coelho et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ncm2a1 dominantly enhances the small wing phenotype caused by expression of argosScer\UAS.cMa under the control of Scer\GAL4Bx-MS1096, but does not enhance the argosScer\UAS.cMa ; Scer\GAL4Bx-MS1096 wing vein loss phenotype.

      (Coelho et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ncmSH0931

      (Coelho et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: a dominant modifier of the small wing phenotype caused by expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096.

      (Coelho et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG127502a1
      (Marygold, 2005.1.19)
      E-2a1
      (Coelho et al., 2005)
      ncm2a1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)