FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\twinDG24102
Open Close
General Information
Symbol
Dmel\twinDG24102
Species
D. melanogaster
Name
FlyBase ID
FBal0177319
Feature type
allele
Associated gene
Dmel\twin
Associated Insertion(s)
P{wHy}twinDG24102
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Joly et al., 2013)

    hypomorphic allele - molecular evidence

    (Joly et al., 2013)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{wHy}twinDG24102
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        100% of germaria lack germline stem cells (GSCs) in the ovaries of 7 day old twinDG24102/Df(3R)Exel6198 females. The loss of GSCs occurs more slowly in the ovaries of homozygous twinDG24102 females: two-thirds of germaria lack GSCs at 3 days, almost 90% lack GSCs at 7 and 14 days, and 100% lack GSCs at 21 days.

        Homozygous clonal GSCs are lost more rapidly from the germaria than control germline clones. Division in the mutant GSCs s slower than in wild type.

        (Joly et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        twinDG24102 has female germline stem cell phenotype, enhanceable by pumMsc/pum[+]

        (Joly et al., 2013)

        twinDG24102 has female germline stem cell phenotype, enhanceable by nanos18/nos[+]

        (Joly et al., 2013)
        Suppressed by
        Statement
        Reference

        twinDG24102 has female germline stem cell phenotype, suppressible | partially by mei-P26fs1/mei-P26[+]

        (Joly et al., 2013)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The loss of germline stem cells seen in the ovaries of homozygous twinDG24102 females is accelerated if the females are also heterozygous for either pumMsc or nos18.

        The loss of germline stem cells seen in the ovaries of homozygous twinDG24102 females is strongly rescued if the females are also heterozygous for mei-P26fs1 .

        (Joly et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        twinDG24102 is rescued by Scer\GAL4VP16.nanos.UTR/twinUASp.Tag:HA

        (Joly et al., 2013)
        Partially rescued by

        twinDG24102 is partially rescued by Scer\GAL4VP16.nanos.UTR/twinmut.UASp.Tag:FLAG

        (Joly et al., 2013)
        Comments

        Expression of twinScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 almost completely rescues the premature loss of germline stem cells seen in the germaria of homozygous twinDG24102 females.

        Expression of twinmut.Scer\UAS.P\T.T:Zzzz\FLAG under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 partially rescues the premature loss of germline stem cells seen in the germaria of homozygous twinDG24102 females.

        (Joly et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        twinDG24102
        (Kordyukova et al., 2020, Joly et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)