FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sdΔ88-159.UAS
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General Information
Symbol
Dmel\sdΔ88-159.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0178072
Feature type
allele
Associated gene
Dmel\sd
Associated Insertion(s)
Carried in Construct
P{UAS-sd.Δ88-159}
Also Known As
UASsdΔ88-159
Key Links
Transgenic product class
inframe_deletion
(Chow et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Chow et al., 2004)
Mutagen
in vitro construct
(Chow et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-sd.Δ88-159}
Cytology
Description

A cDNA fragment corresponding to sd with an internal deletion, removing amino acids 88-159, is expressed under the control of UASt regulatory sequences. This deletion removes the sd TEA domain.

(Chow et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of sdΔ88-159.Scer\UAS in the wing disc (under the control of Scer\GAL4sd-SG29.1) produces elongated pupae and adults and causes loss of the adult wing.

      Expression of sdΔ88-159.Scer\UAS in muscle cells under the control of Scer\GAL4Mef2.PR results in 78% pupal lethality. Larvae exhibit obvious gaps between the dorsal acute (DA)1 muscles are larger than in wild-type, suggesting the elongated body type is caused by muscle defects.

      Expression of sdΔ88-159.Scer\UAS at early embryo developmental stages (7-11) under the control of Scer\GAL4twi.PG does not lead to elongated adults and significant lethality.

      (Deng et al., 2010)

      Expression of sdΔ88-159.Scer\UAS, driven by Scer\GAL4vg.boundary, leads to an enhancement of the wing phenotypes seen in sdETX4 and sd58d mutants. Overexpression of sdΔ88-159.Scer\UAS driven by Scer\GAL4vg.boundary leads to a defective wing phenotype in wild-type flies.

      (Chow et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of both vgUAS.Tag:HA and sdΔ88-159.UAS in developing muscles under the control of Scer\GAL4Mef2.PR results in fewer ectopic muscle attachments (24.5% compared with 81.8% when vgUAS.Tag:HA is expressed alone).

      (Deng et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sdΔ88-159.Scer\UAS
      sdΔ88-159.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)