FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\robo1ΔCC2CC3.UAS.Tag:MYC
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General Information
Symbol
Dmel\robo1ΔCC2CC3.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0178179
Feature type
allele
Associated gene
Dmel\robo1
Associated Insertion(s)
Carried in Construct
P{UAS-robo1.ΔCC2CC3-myc}
Key Links
Transgenic product class
inframe_deletion
(Godenschwege et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Godenschwege et al., 2002)
Mutagen
in vitro construct
(Godenschwege et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-robo1.ΔCC2CC3-myc}
Cytology
Description

UAS regulatory sequences drive expression of a deleted form of robo1 that lacks the CC2 and CC3 motifs. The protein is tagged with Tag:MYC.

(Godenschwege et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
robo1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of roboΔCC2CC3.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4A307 rarely induces a "bendless"-like phenotype (the end of the giant fiber (GF) is either swollen or tapered). Expression of roboΔCC2CC3.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4c17 does not induce a "bendless"-like phenotype. Expression of roboΔCC2CC3.Scer\UAS.T:Hsap\MYC, under the regulation of Scer\GAL4A307 results in complete lateral deflection of the larval giant fiber, compared to expression of roboΔCC2CC3.Scer\UAS.T:Hsap\MYC under the regulation of Scer\GAL4c17, where lateral deflection can occur in 13% of cases. Expression of roboΔCC2CC3.Scer\UAS.T:Hsap\MYC, under the regulation of Scer\GAL4shakB.lethal.4.1 results in the anatomical and physiological disruption of tergal depressor of trochanter muscle motor neuron & dendrites with a 100% penetrance.

      (Godenschwege et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      robo1ΔCC2CC3.Scer\UAS.T:Hsap\MYC
      robo1ΔCC2CC3.UAS.Tag:MYC
      roboΔCC2CC3.Scer\UAS.T:Hsap\MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)