FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mysb13
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General Information
Symbol
Dmel\mysb13
Species
D. melanogaster
Name
FlyBase ID
FBal0178762
Feature type
allele
Associated gene
Dmel\mys
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jannuzi et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: E274V.

(Jannuzi et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:8,067,066..8,067,066 [+]
Nucleotide change:

A8067066T

Amino acid change:

E274V | mys-PA; E274V | mys-PB; E274V | mys-PC; E274V | mys-PD

Reported amino acid change:

E274V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Jannuzi et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      10% of mutant males raised at 18-22[o]C through the first or second larval instar stages and then shifted to 28[o]C prior to pupal development have an under-rotated genitalia phenotype. The frequency of rotation defects is reduced if the flies are reared at 22[o]C.

      (Fraichard et al., 2010)

      Strong allele.

      (Jannuzi et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      if3, mysb13 has male genitalia phenotype

      (Fraichard et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      100% of mysb13 if3 double mutant males have under-rotated genitalia at 22[o]C, with 61% of them being greater than 180[o] under-rotated.

      (Fraichard et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: Extraneous lethal mutations on the chromosome.

      (Fraichard et al., 2010)

      Selected as: a mutation that permits the survival of an F1 male.

      (Jannuzi et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mysb13
      (Hartman et al., 2015, Fraichard et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)