FlyBase Allele Report: Dmel\zip[z2097]

General Information

Symbol

Dmel\zip^z2097

Species

D. melanogaster

Name

FlyBase ID

FBal0180552

Feature type

allele

Associated gene

Dmel\zip

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Sechi et al., 2020)

Mutagen

ethyl methanesulfonate

(Giansanti et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: I?F.

(Sechi et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:24,995,451..24,995,451 [-]

Nucleotide change:

A24995451T

Amino acid change:

Comment:

Site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change. A second point mutation relative to the iso-1 reference sequence was reported, a T to P substitution at the N-terminus, but this substitution was present in the starting strain prior to mutagenesis.

(Sechi et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis | male | recessive

(Giansanti et al., 2004)

abnormal meiotic cell cycle | male (with Df(2R)BSC608)

(Sechi et al., 2020)

abnormal meiotic cell cycle | male (with zip¹)

(Sechi et al., 2020)

abnormal meiotic cell cycle | male (with zip²)

(Sechi et al., 2020)

abnormal meiotic cell cycle | male | recessive

(Giansanti et al., 2004)

abnormal mitotic cell cycle | third instar larval stage (with Df(2R)BSC608)

(Sechi et al., 2020)

male sterile (with Df(2R)BSC608)

(Sechi et al., 2020)

male sterile (with zip¹)

(Sechi et al., 2020)

male sterile (with zip²)

(Sechi et al., 2020)

Phenotype Manifest In

contractile ring & meiotic cell cycle | male

(Giansanti et al., 2004)

contractile ring | third instar larval stage (with Df(2R)BSC608)

(Sechi et al., 2020)

filamentous actin | male (with Df(2R)BSC608)

(Sechi et al., 2020)

larval neuroblast | third instar larval stage (with Df(2R)BSC608)

(Sechi et al., 2020)

male germ cell nucleus | increased number (with Df(2R)BSC608)

(Sechi et al., 2020)

male germ cell nucleus | increased number (with zip¹)

(Sechi et al., 2020)

male germ cell nucleus | increased number (with zip²)

(Sechi et al., 2020)

Nebenkern

(Giansanti et al., 2004)

onion stage spermatid (with Df(2R)BSC608)

(Sechi et al., 2020)

onion stage spermatid (with zip¹)

(Sechi et al., 2020)

onion stage spermatid (with zip²)

(Sechi et al., 2020)

spermatid & nucleus | supernumerary

(Giansanti et al., 2004)

spermatocyte (with Df(2R)BSC608)

(Sechi et al., 2020)

spindle & meiotic cell cycle | male

(Giansanti et al., 2004)

Detailed Description

Statement

Reference

zip^z2097/Df(2R)BSC608, zip^z2097/zip¹ or zip^z2097/zip² males exhibit multinucleate onion stage spermatids.

zip^z2097/Df(2R)BSC608 spermatocytes exhibit F-actin rings that are substantially thinner and fail to constrict.

zip^z2097/Df(2R)BSC608 third instar larval neuroblasts at late telophase fail to pinch the central spindle midzone during cytokinesis and dividing neuroblasts exhibit defective contractile rings.

(Sechi et al., 2020)

A large proportion of cbe^Z2097 mutant spermatids have one large nebenkern with four nuclei of normal size, indicating a cytokinetic failure in both meiotic divisions. A smaller proportion have two nuclei and a large nebenkern, indicating failure of only one of the meiotic divisions. Spermatocytes of cbe^Z2097 mutants lack an organized central spindle and an F-actin ring throughout ana-telophase. The equatorial anillin band is present but fails to constrict properly.

(Giansanti et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

cbe^Z2097

cbe^z2097

(Sechi et al., 2020)

zip^z2097

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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