FlyBase Allele Report: Dmel\Syn[1-12.UAS]

General Information

Symbol

Dmel\Syn^1-12.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0181358

Feature type

allele

Associated gene

Dmel\Syn

Associated Insertion(s)

Carried in Construct

P{UAS-Syn.1-12}

Also Known As

UAS-syn

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Lohr et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-Syn.1-12}

Cytology

Description

UASt sequences drive expression of Syn. The Syn region was created from a Xho-PshAI 3.1 kb fragment (containing exon 1, intron 1, and part of exon 2) and a PshAI-XbaI fragment (containing part of exon 2 and exons 3-13).

(Lohr et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Syn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/Syn^1-12.UAS rescues Syn⁹⁷

(Michels et al., 2011)

Scer\GAL4^elav-C155, Syn^1-12.UAS, Scer\GAL80^ts.αTub84B rescues Syn⁹⁷

(Michels et al., 2011)

Scer\GAL4^Mef2.247/Syn^1-12.UAS rescues Syn⁹⁷

(Michels et al., 2011)

Fails to rescue

Syn^1-12.UAS/Scer\GAL4^GH146 fails to rescue Syn⁹⁷

(Michels et al., 2011)

Syn^1-12.UAS/Scer\GAL4^NP0225 fails to rescue Syn⁹⁷

(Michels et al., 2011)

Comments

Pan-neuronal expression of Syn^{1-12.Scer\UAS}, under the control of Scer\GAL4^elav-C155 fully rescues associative learning in Syn⁹⁷ mutants.

Pan-neuronal acute expression of Syn^{1-12.Scer\UAS}, through heat-shocking of flies carrying Scer\GAL80^ts.αTub84B as well as Scer\GAL4^elav-C155 (where Scer\GAL80^ts.αTub84B blocks expression until heat-shock), fully rescues the associative odor-sugar learning in Syn⁹⁷ mutants.

Expression of Syn^{1-12.Scer\UAS} in the mushroom bodies, under the control of Scer\GAL4^Mef2.247, fully rescues the associative odor-sugar learning in Syn⁹⁷ mutants.

Expression of Syn^{1-12.Scer\UAS} in a subset of the mushroom body neurons, under the control of Scer\GAL4^D52H, fully rescues the associative odor-sugar learning in Syn⁹⁷ mutants.

Expression of Syn^{1-12.Scer\UAS} in the projection neurons, under the control of either Scer\GAL4^GH146 or Scer\GAL4^NP0225, fails to rescue the associative odor-sugar learning in Syn⁹⁷ mutants.

Expression of Syn^{1-12.Scer\UAS} in all neurons except those in the mushroom body, under the control of both Scer\GAL4^elav-C155 and Scer\GAL80^Mef2.PT does not rescue odor-sugar associative learning in Syn⁹⁷ mutants.

(Michels et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Syn^{1-12.Scer\UAS}

Syn^1-12.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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