Moe^c858 homozygotes have abnormal wing phenotypes of variable penetrance and expressivity. The most weakly affected wings have a malformed and reduced hinge, and a wing blade shortened along the proximal-distal axis. Vein pattern in the wing blade is compressed along this axis but otherwise largely normal in the most weakly affected. More severely affected wings are smaller still, form vesicles between the dorsal and ventral surfaces of the wing and have veination defects mainly affecting L3. The vesicles differentiate trichomes characteristic of the wing blade and hinge. L3 often forms rings of vein tissue or is severely thickened. The reduction in wing size is caused in part by an increase in cell density, and by a decrease in cell number between L3 and L4 (1st posterior cell). The same range of phenotypes are seen in Moe^PL106/Moe^c858 and Moe^G0323/Moe^c858. The penetrance of moderate to severe phenotypes is lower in Moe^PL106/Moe^c858 animals than in the other two genotypes.

In the late third instar wing disc of Moe^c858 homozygotes, the apical-basal organisation of disc cells appears normal, but the cells are more flattened that in wild-type and tha basal lamina is disorganised and has leisions. Disruption of the basal lamina is most apparent in the prospective hinge. In a fraction of these discs, the epithelium is folded back under the disc making transverse sections multi-layered.

Expression of Moe^C858 under the control of Scer\GAL4^dpp.3KK results in wing vein thickening.

Expression of Moe^C858 under the control of Scer\GAL4^MD-638 results in reduced wing size.

Expression of Moe^C858 under the control of Scer\GAL4^sca-C253 does not result in a mutant phenotype.

Mutants have smaller wings than normal, an abnormal wing hinge, alterations in the pattern of the L3 vein and vesicles of wing tissue differentiating trapped between the dorsal and ventral wing surfaces. The wing imaginal discs show profound alterations in morphology compared to wild type.

Moe^C858 has wing phenotype, non-enhanceable by tkv⁴/tkv[+]

Moe^C858 has wing phenotype, non-enhanceable by dpp^d12/dpp[+]

Moe^C858 has wing phenotype, non-enhanceable by ptc⁹/ptc[+]

Moe^C858 has wing vein L3 phenotype, suppressible by Rho1^k07236/Rho1[+]

Moe^C858 has wing phenotype, suppressible by Rho1^k07236/Rho1[+]

Moe^C858 has wing phenotype, non-suppressible by tkv⁴/tkv[+]

Moe^C858 has wing phenotype, non-suppressible by dpp^d12/dpp[+]

Moe^C858 has wing phenotype, non-suppressible by ptc⁹/ptc[+]