FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\APPΔNPTY.UAS.Tag:MYC
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General Information
Symbol
Hsap\APPΔNPTY.UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0183234
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-Hsap\APP.ΔNPTY}
Key Links
Transgenic product class
inframe_deletion
(Merdes et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Merdes et al., 2004)
Mutagen
in vitro construct
(Merdes et al., 2004)
Progenitor genotype
Hsap\APPUAS.Tag:MYC
(Merdes et al., 2004)
Carried in construct
P{UAS-Hsap\APP.ΔNPTY}
Cytology
Description

Amino acids NGYENPTYKFF (681 - 691) have been deleted.

(Merdes et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APP
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      ventral adult lateral neuron & axon, with Scer\GAL4P2.4.Pdf

      (Leyssen et al., 2005)
      Detailed Description
      Statement
      Reference

      Flies with Hsap\APPΔNPTY.Scer\UAS.T:Hsap\MYC overexpressed by Scer\GAL4Appl.G1a do not have wing expansion defects.

      (Peng et al., 2015)

      Expression of Hsap\APPΔNPTY.Scer\UAS.T:Hsap\MYC (under the control of either Scer\GAL4elav-C155 or Scer\GAL4179Y) in larval axons does not affect axonal transport.

      (Rusu et al., 2007)

      Expression of Hsap\APPΔNPTY.Scer\UAS.T:Hsap\MYC, under the control of Scer\GAL4P2.4.Pdf, does not cause increased arborization of the sLNv , and in rare cases (4/24) reduces the normal axonal arbour.

      (Leyssen et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\APPΔNPTY.Scer\UAS.T:Hsap\MYC
      Hsap\APPΔNPTY.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)