FlyBase Allele Report: Dmel\Dcr-1[Q1948X]

General Information

Symbol

Dmel\Dcr-1^Q1948X

Species

D. melanogaster

Name

FlyBase ID

FBal0184191

Feature type

allele

Associated gene

Dmel\Dcr-1

Associated Insertion(s)

Carried in Construct

Also Known As

dcr-1^d102

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone

(Xu et al., 2008)

decreased cell growth rate | somatic clone | third instar larval stage

(Herranz et al., 2010)

decreased occurrence of cell division | germline clone | oogenesis

(Hatfield et al., 2005)

Phenotype Manifest In

abdominal 1 dorsal multidendritic neuron ddaC | somatic clone

(Xu et al., 2008)

dendrite | somatic clone

(Xu et al., 2008)

germline stem cell | germline clone

(Hatfield et al., 2005)

ovariole | germline clone

(Hatfield et al., 2005)

wing disc | somatic clone | third instar larval stage

(Herranz et al., 2010)

Detailed Description

Statement

Reference

Wing disc clones of Dcr-1^Q1948X mutant cells are on average smaller than their corresponding wild-type twin clones.

(Herranz et al., 2010)

Dcr-1^d102 MARCM clones do not exhibit a significantly reduced number of dendritic ends of ddaC neurons; however, terminal branches fail to elaborate properly.

(Xu et al., 2008)

Mutant germline stem-cells (GSCs) show normal spectrosome morphology and position, when germ-line clones are made. The frequency of cell division in mutant GSCs is reduced to 41% of normal levels.

(Hatfield et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dcr-1^Q1948X is a suppressor | somatic clone of abnormal neuroanatomy | somatic clone | larval stage phenotype of Delta::N^ΔECN.UAS, Scer\GAL4^elav.PU

(Wu et al., 2017)

Dcr-1^Q1948X is a suppressor | somatic clone of neoplasia | somatic clone | larval stage phenotype of Delta::N^ΔECN.UAS, Scer\GAL4^elav.PU

(Wu et al., 2017)

Dcr-1^Q1948X is a suppressor | somatic clone of increased cell number | somatic clone | larval stage phenotype of Delta::N^ΔECN.UAS, Scer\GAL4^elav.PU

(Wu et al., 2017)

Dcr-1^Q1948X is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4⁴⁷⁷, mir-124^UAS.cXa

(Xu et al., 2008)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dcr-1^Q1948X is a suppressor | somatic clone of type II neuroblast | increased number | somatic clone | larval stage phenotype of Delta::N^ΔECN.UAS, Scer\GAL4^elav.PU

(Wu et al., 2017)

Dcr-1^Q1948X is a suppressor | somatic clone of larval brain | somatic clone | larval stage phenotype of Delta::N^ΔECN.UAS, Scer\GAL4^elav.PU

(Wu et al., 2017)

Dcr-1^Q1948X is a suppressor of abdominal 1 dorsal multidendritic neuron ddaC phenotype of Scer\GAL4⁴⁷⁷, mir-124^UAS.cXa

(Xu et al., 2008)

Dcr-1^Q1948X is a suppressor of dendrite phenotype of Scer\GAL4⁴⁷⁷, mir-124^UAS.cXa

(Xu et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Ectopic expression of mir-124^Scer\UAS.cXa in homozygous Dcr-1^d102 ddaC neuron clones (under the control of Scer\GAL4⁴⁷⁷) does not affect the number of dendritic ends, indicating Dcr-1 suppression of mir-124 function.

(Xu et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32067

P{GMR-w.RNAi}13D; P{neoFRT}82B Dcr-1^Q1948X/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dcr-1^Q1948X

(Hanyu-Nakamura et al., 2019, Wu et al., 2017, Carthew, 2010.7.27)

Dcr-1^d102

(Carthew, 2010.7.27)

dcr-1^d102

(Herranz et al., 2010, Xu et al., 2008, Bilen et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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