FlyBase Allele Report: Dmel\Rbfox1[e03440]

General Information

Symbol

Dmel\Rbfox1^e03440

Species

D. melanogaster

Name

FlyBase ID

FBal0186199

Feature type

allele

Associated gene

Dmel\Rbfox1

Associated Insertion(s)

PBac{RB}Rbfox1^e03440

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Gene Disruption Project members and Exelixis, 2005)

Progenitor genotype

Associated Insertion(s)

PBac{RB}Rbfox1^e03440

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{RB}

gene trap

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:10,531,667..10,531,667 [-]

(Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile (with Rbfox1^f02600)

(Tastan et al., 2010)

female sterile (with Df(3L)ED4457)

(Carreira-Rosario et al., 2016)

female sterile | recessive

(Tastan et al., 2010)

Phenotype Manifest In

female germline cell (with Rbfox1^f02600)

(Tastan et al., 2010)

female germline cell | germline clone

(Tastan et al., 2010)

female germline cell | increased number (with Df(3L)ED4457)

(Carreira-Rosario et al., 2016)

ovary (with Rbfox1^KG06463)

(Tastan et al., 2010)

Detailed Description

Statement

Reference

Rbfox1^e03440/Df(3L)ED4457 results in female sterility and a germ cell tumor phenotype (accumulation of germline cysts that fail to differentiate beyond early stages).

(Carreira-Rosario et al., 2016)

Homozygous germline clones fail to differentiate properly and become tumorous. Egg chambers in which the entire follicle cell layer is homozygous appear normal through the early stages of oogenesis.

Germline cysts from A2bp1^KG06463/A2bp1^e03440 ovaries show germ cell counting defects at high penetrance and a mildly tumorous phenotype at low penetrance.

A2bp1^f02600/A2bp1^e03440 females are weakly fertile, but nearly all cysts cells undergo an extra mitotic division so that the egg chambers contain 32 germline cells.

(Tastan et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Rbfox1^f02600/Rbfox1^e03440, bru1^QB has female sterile phenotype

(Tastan et al., 2010)

Phenotype Manifest In