FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mague00439
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General Information
Symbol
Dmel\mague00439
Species
D. melanogaster
Name
FlyBase ID
FBal0186626
Feature type
allele
Associated gene
Dmel\magu
Associated Insertion(s)
PBac{RB}mague00439
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{RB}mague00439
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mague00439 homozygotes and mague00439/maguf02256 transheterozygotes are viable and exhibit a wing vein defect.

      mague00439/maguf02256 transheterozygous testes contain fewer germ cells. The median germline stem cell number per testis is only 3, whereas sibling controls carry a median of 8 germline stem cells at 3rd instar larval stage. Moreover, mutant testes display germ cells with branched fusomes next to the hub, indicating that they have differentiated and are no longer bona fide stem cells.

      (Zheng et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of tkvQ199D.Scer\UAS.T:Ivir\HA1 using the germ cell driver Scer\GAL4nos.UTR.T:Hsim\VP16 raises the fraction of testes with germline stem cells from 63% to 100% in a mague00439/maguf02256 background. The median germline stem cell number also doubles compared to that observed in mutants.

      (Zheng et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mague00439/maguf02256 is rescued by maguUAS.Tag:V5/Scer\GAL4upd1.PU

      (Zheng et al., 2011)
      Comments

      Expression of maguScer\UAS.T:SV5\V5 under the control of Scer\GAL4upd in mague00439/maguf02256 flies aged at 29[o]C partially rescues the number of germline stem cells. The fraction of testes with germline stem cells increases to more than 50% and sometimes approaches or equals 100%. Partial rescue occurs in both flies aged 3 days and 12 days. A similar rescue is displayed for the wing vein phenotype.

      (Zheng et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG2264e00439
      mague00439
      Name Synonyms
      Secondary FlyBase IDs
        References (2)