FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Itgbn2
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General Information
Symbol
Dmel\Itgbn2
Species
D. melanogaster
Name
FlyBase ID
FBal0188371
Feature type
allele
Associated gene
Dmel\Itgbn
Associated Insertion(s)
Carried in Construct
Also Known As
βν2, betaInt-nu2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Devenport and Brown, 2004)
Progenitor genotype
P{EP}EP2030
(Devenport and Brown, 2004)
Cytology
Description

Imprecise excision of P{EP}EP2030 has produced a 2494bp deletion which removes the first 8 codons of βInt-ν and approximately 2kb of upstream regulatory sequence.

(Devenport and Brown, 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Itgbn2 mutant embryonic hemocytes show a decreased competence to undertake phagocytosis of apoptotic cells, despite of no changes in proportions of hemocytes or apoptotic cells in those embryos, as compared to controls. These mutants do not show a delay in development to adulthood, as compared to controls.

      (Nagaosa et al., 2011)

      Significant overgrowth of the neuromuscular junction (NMJ) (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in βInt-ν1/βInt-ν2 third instar larvae.

      (Tsai et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Itgbn2 has embryonic/larval hemocyte phenotype, enhanceable by drprΔ5

      (Nagaosa et al., 2011)
      Enhancer of
      Statement
      Reference

      Itgbn2 is an enhancer of embryonic/larval hemocyte phenotype of drprΔ5

      (Nagaosa et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Itgbn2, drprΔ5 double mutants show a significant delay in development to adulthood, as compared to wild-type controls and either single mutants.

      (Nagaosa et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Itgbn2 is rescued by ItgbnUAS.cNa/Scer\GAL4srp.Hemo

      (Nagaosa et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      No transcript visible by in situ to stage 13 or 15 embryos.

      (Devenport and Brown, 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Itgbn2
      Itgβν2
      betaInt-nu2
      (Nainu et al., 2015, Nonaka et al., 2013, Nagaosa et al., 2011)
      β-Int ν2
      (Nakano et al., 2019)
      βInt-ν2
      βν2
      (Tsai et al., 2012, Tsai et al., 2008, Becam et al., 2005, Devenport and Brown, 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)