FB2026_02 , released June 18, 2026
Allele: Dmel\EcRB2-ΔC655.F645A.UAS
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General Information
Symbol
Dmel\EcRB2-ΔC655.F645A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0189562
Feature type
allele
Associated gene
Dmel\EcR
Associated Insertion(s)
Carried in Construct
P{UAS-EcR.B2.F645A}
Key Links
Transgenic product class
inframe_deletion
(Cherbas, 2006.3.19)
missense_variant
(Cherbas, 2006.3.19)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Cherbas, 2006.3.19)
missense_variant
(Cherbas, 2006.3.19)
Mutagen
in vitro construct
(Cherbas, 2006.3.19)
Progenitor genotype
Carried in construct
P{UAS-EcR.B2.F645A}
Cytology
Description

UAS regulatory sequences drive expression of a mutated EcR B2 isoform (carries the amino acid replacement F645A) that is truncated after residue 655.

(Cherbas, 2006.3.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
EcR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by ph-d505, ph-p505
      (Jiang et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of EcRB2-ΔC655.F645A.Scer\UAS strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.

      (Sinenko et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EcRB2-ΔC655.F645A.Scer\UAS
      EcRB2-ΔC655.F645A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (12)