FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pixL35
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General Information
Symbol
Dmel\pixL35
Species
D. melanogaster
Name
FlyBase ID
FBal0189565
Feature type
allele
Associated gene
Dmel\pix
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Coelho et al., 2005)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: P146L.

    (Coelho et al., 2005)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:8,973,848..8,973,848 [-]
    Nucleotide change:

    C8973848T

    Amino acid change:

    P146L | pix-PA; P146L | pix-PB

    Reported amino acid change:

    P146L

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Coelho et al., 2005)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Weak allele. pixL35 flies show no developmental delay and adults have wings of the same area as wild-type controls. pixL35/pixL24 flies have a slow developmental time (12-13.5 days) compared to wild-type flies (10 days). Adult flies are smaller than wild type with a decreased wing area, slender, short thoracic macrochaetae and occasional eye roughening. pixL35/pixL17 show the same phenotype, except that the developmental time is 12-15 days. pixL35/pixL17 wing discs display distinct patterns of elevated apoptosis; there are uniformly distributed clusters of apoptotic cells during the early to late mid third instar, followed by a transient period during the late third instar when apoptosis is intense in the wing pouch. Shortly before pupation, apoptosis is less intense and more uniformly distributed. The resulting adult wings are patterned normally.

        (Coelho et al., 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of BacA\p35Scer\UAS.cHa in the posterior compartment of pixL35/pixL17 wing discs, driven by Scer\GAL4en-e16E, increases the area of the posterior compartment relative to control wings that also express BacA\p35Scer\UAS.cHa in the posterior.

        (Coelho et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference

        Expression of BacA\p35Scer\UAS.cHa in the posterior compartment of pixL35/pixL17 wing discs, driven by Scer\GAL4en-e16E, increases the area of the posterior compartment relative to control wings that also express BacA\p35Scer\UAS.cHa in the posterior.

        (Coelho et al., 2005)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        pixL35
        (Coelho et al., 2005)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)