FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CheB42aΔ5-68
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General Information
Symbol
Dmel\CheB42aΔ5-68
Species
D. melanogaster
Name
FlyBase ID
FBal0189632
Feature type
allele
Associated gene
Dmel\CheB42a
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lin et al., 2005)
Progenitor genotype
P{SUPor-P}mimKG05881
(Lin et al., 2005)
Cytology
Description

Imprecise excision of P{SUPor-P}KG05881 generates a genomic deletion removing the 5' section and upstream promoter regions of CheB42a.

(Lin et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CheB42aΔ5-68 does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

      (Shankar et al., 2015)

      CheB42aΔ5-68 mutant males perform an average of eight attempted copulations in a 10 min observation period, whereas control males perform only three. This increased number results from a faster progression from initiation of courtship behaviour to the first attempted copulation, as well as more frequent subsequent attempts.

      CheB42aΔ5-68 males are not different from controls in the timing or frequency of earlier steps in the courtship sequence (lag to courtship initiation, tracking and following of the female, tapping, and wing vibration).

      CheB42aΔ5-68 homozygous males spend the same amount of time courting females as wild-type controls. CheB42aΔ5-68 has no effect on several other behaviours unrelated to courtship; such behaviours include preening, walking, geotaxis, and gustatory response to sugars.

      (Park et al., 2006)

      Males homozygous for CheB42aΔ5-68 display normal levels of overall courtship. The typical climbing response to mechanosensory detection of gravity, stimulation of food intake by gustatory detection of sucrose is not affected in CheB42aΔ5-68 homozygous males.

      (Lin et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In contrast to their different responses to wild-type females, CheB42aΔ5-68 and wild-type males attempt to copulate with heat-shocked females expressing traScer\UAS.cFa under the control of Scer\GAL4hs.PB with indistinguishable frequency and kinetics, suggesting that the behavioural effect of CheB42a depends on the presence of the major female cuticular hydrocarbons.

      Partially-transformed males, where traScer\UAS.cFa under the control of Scer\GAL4oeE is expressed in the oenocytes, elicit significant courtship responses both from controls and CheB42aΔ5-68 males. Mutant males outperform controls specifically in the kinetics and frequency of attempted copulations.

      (Park et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      CheB42aΔ5-68 is rescued by CheB42a+tTg1

      (Park et al., 2006)
      Not rescued by

      CheB42aΔ5-68 is not rescued by CheB42aATGmut.+tTg1

      (Park et al., 2006)
      Comments

      CheB42aΔ5-68 rescues the accelerated progression towards attempted copulation and its increased frequency found in CheB42aΔ5-68 males.

      (Park et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CheB42aΔ5-68
      (Shankar et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)