FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pip3
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General Information
Symbol
Dmel\pip3
Species
D. melanogaster
Name
FlyBase ID
FBal0190373
Feature type
allele
Associated gene
Dmel\pip
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhu et al., 2005)
Progenitor genotype
Cytology
Description

Mutation is within the third exon of the pip transcript and affects all pip isoforms.

(Zhu et al., 2005)

Amino acid replacement: Q95term.

(Zhu et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,313,158..19,313,158 [-]
Nucleotide change:

C19313158T

Amino acid change:

Q105term | pip-PA; Q105term | pip-PC; Q105term | pip-PD; Q105term | pip-PF; Q105term | pip-PG; Q105term | pip-PH; Q105term | pip-PI; Q105term | pip-PJ; Q105term | pip-PK; Q105term | pip-PL; Q105term | pip-PN

Reported amino acid change:

Q95term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Difference between reported and FlyBase amino acid change due to authors use of GenBank record gi:7293803 which has since been replaced by a new version gi:28380469 .

(Zhu et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pip3/Df(3L)pipeA13 transheterozygotes are semi-lethal, producing only 21% of the expected number of progeny. These progeny eclose an average of 3 days later than wild-type flies and are small. In contrast to wild-type embryos, there are no detectable sulfated glycans in the salivary glands of pip3 embryos.

      (Zhu et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of eaScer\UAS.P\T.T:Ivir\HA1 and snkScer\UAS.P\T.T:Avic\GFP-m6 using Scer\GAL4unspecified in a pip1/pip3 background results in the production of dorsalized embryos.

      (Cho et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      K. Anderson

      (Zhu et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pip3
      (Sergeev et al., 2001)
      pipe3
      (Cho et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)