FlyBase Allele Report: Dmel\DJ-1α[UAS.cMa]

General Information

Symbol

Dmel\DJ-1α^UAS.cMa

Species

D. melanogaster

Name

FlyBase ID

FBal0190389

Feature type

allele

Associated gene

Dmel\DJ-1α

Associated Insertion(s)

Carried in Construct

P{UAS-DJ-1α.M}

Key Links

Transgenic product class

cDNA

(Meulener, 2005)

wild_type

(Meulener, 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Meulener, 2005)

wild_type

(Meulener, 2005)

Mutagen

in vitro construct

(Meulener, 2005)

Progenitor genotype

Carried in construct

P{UAS-DJ-1α.M}

Cytology

Description

UAS sequences drive expression of the cDNA corresponding to the DJ-1α gene.

(Meulener, 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

DJ-1α

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Sajjad et al., 2014)

exacerbates mitochondrial DNA depletion syndrome 15

modeled by TFAM^NIG.4217R, TFAM^c01716

(Duncan et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies with expression of DJ-1α^Scer\UAS.cMa driven by Scer\GAL4^GMR.PU display normal eye development and ultrastructure.

(Aron et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Ret^MEN2A.UAS, Scer\GAL4^GMR.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa/Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Ras85D^G12V.sev

(Aron et al., 2010)

DJ-1α^UAS.cMa/Scer\GAL4^GMR.PU is an enhancer of increased cell number | adult stage phenotype of Ras85D^G12V.sev

(Aron et al., 2010)

NOT Enhancer of

Statement

Reference

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of increased cell number | adult stage phenotype of Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^GMR.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Akt^UAS.cUa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of increased cell size | adult stage phenotype of Akt^UAS.cUa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

Suppressor of

Statement

Reference

DJ-1α^UAS.cMa, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Sajjad et al., 2014)

DJ-1α^UAS.cMa, Scer\GAL4^ey.PU is a suppressor | partially of visible phenotype of Pten^UAS.cKa, Scer\GAL4^ey.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^ey.PU is a suppressor | partially of decreased cell size | adult stage phenotype of Pten^UAS.cKa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Ret^MEN2A.UAS, Scer\GAL4^GMR.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa/Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Ras85D^G12V.sev

(Aron et al., 2010)

DJ-1α^UAS.cMa/Scer\GAL4^GMR.PU is an enhancer of eye photoreceptor cell | adult stage | increased number phenotype of Ras85D^G12V.sev

(Aron et al., 2010)

NOT Enhancer of

Statement

Reference

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of eye photoreceptor cell | adult stage | increased number phenotype of Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^GMR.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Akt^UAS.cUa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU is a non-enhancer of ommatidium phenotype of Akt^UAS.cUa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

Suppressor of

Statement

Reference

DJ-1α^UAS.cMa, Scer\GAL4^elav-C155 is a suppressor of rhabdomere phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Sajjad et al., 2014)

DJ-1α^UAS.cMa, Scer\GAL4^ey.PU is a suppressor | partially of eye phenotype of Pten^UAS.cKa, Scer\GAL4^ey.PU

(Aron et al., 2010)

DJ-1α^UAS.cMa, Scer\GAL4^ey.PU is a suppressor | partially of ommatidium phenotype of Pten^UAS.cKa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of DJ-1α^UAS.cMa enhances severity of the small rough eye phenotype in flies with Ret^MEN2A.UAS driven by Scer\GAL4^GMR.PU. Co-expression of DJ-1α^UAS.cMa does not enhance eye and ommatidial size phenotypes in flies with expression of Akt1^UAS.cUa driven by Scer\GAL4^GMR.PU. Co-expression of DJ-1α^UAS.cMa does not enhance increases in eye size in flies with expression of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)} driven by Scer\GAL4^GMR.PU. Co-expression of DJ-1α^UAS.cMa significantly partially suppresses the decreases in eye and ommatidial size seen in flies with expression of Pten^UAS.cKa driven by Scer\GAL4^ey.PU. Co-expression of DJ-1α^UAS.cMa does not alter eye phenotypes in flies with expression of rl^Sem.cUa.UAS driven by Scer\GAL4^GMR.PU.

(Aron et al., 2010)

Expression of the DJ-1α^Scer\UAS.cMa transgene, under the control of Scer\GAL4^αTub84B.PL, rescues the sensitivity of dj-1β^Δ93; DJ-1α^Δ72 mutants to paraquat.

(Meulener et al., 2005)

Xenogenetic Interactions

Statement

Reference

Expression of DJ-1α^Scer\UAS.cMa suppresses the rhabdomere degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

(Sajjad et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33603

w¹¹¹⁸; P{UAS-DJ-1α.M}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DJ-1α^Scer\UAS.cMa

DJ-1α^UAS.cMa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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