FlyBase Allele Report: Dmel\Pten[UAS.cKa]

General Information

Symbol

Dmel\Pten^UAS.cKa

Species

D. melanogaster

Name

FlyBase ID

FBal0197152

Feature type

allele

Associated gene

Dmel\Pten

Associated Insertion(s)

Carried in Construct

P{UAS-Pten.K}

Also Known As

UAS-dPTEN

Key Links

Transgenic product class

cDNA

(Kim et al., 2005)

wild_type

(Kim et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Kim et al., 2005)

wild_type

(Kim et al., 2005)

Mutagen

in vitro construct

(Kim et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-Pten.K}

Cytology

Description

UASt regulatory sequences drive expression of a Pten cDNA.

(Kim et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Pten

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell size | adult stage, with Scer\GAL4^ey.PU

(Aron et al., 2010)

lethal, with Scer\GAL4^ey.PH

(Kim et al., 2005)

visible, with Scer\GAL4^ey.PH

(Kim et al., 2005)

visible, with Scer\GAL4^ey.PU

(Aron et al., 2010)

visible, with Scer\GAL4^GMR.PF

(Kim et al., 2005)

visible, with Scer\GAL4^GMR.PU

(Aron et al., 2010)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PU

(Aron et al., 2010)

eye, with Scer\GAL4^GMR.PF

(Kim et al., 2005)

eye, with Scer\GAL4^GMR.PU

(Aron et al., 2010)

ommatidium, with Scer\GAL4^ey.PU

(Aron et al., 2010)

Detailed Description

Statement

Reference

Expression of Pten^Scer\UAS.cKa driven by Scer\GAL4^ey.PU leads to significant decreases in eye and ommatidial size; expression driven by Scer\GAL4^GMR.PU leads to reduced eye size.

(Aron et al., 2010)

Expression of Pten^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF results in a 30% decrease in eye size compared to controls.

Expression of Pten^Scer\UAS.cKa under the control of Scer\GAL4^ey.PH results in an 80% decrease in eye size compared to controls.

(Kim et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pten^UAS.cKa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by DJ-1α[+]/DJ-1α^k04204

(Kim et al., 2005)

Suppressed by

Statement

Reference

Pten^UAS.cKa, Scer\GAL4^ey.PU has visible phenotype, suppressible | partially by dj-1β^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has decreased cell size | adult stage phenotype, suppressible | partially by dj-1β^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has visible phenotype, suppressible | partially by DJ-1α^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has decreased cell size | adult stage phenotype, suppressible | partially by DJ-1α^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has visible phenotype, suppressible | partially by Ret^UAS.cLa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has decreased cell size | adult stage phenotype, suppressible | partially by Ret^UAS.cLa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Hsap\PARK7^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2005)

NOT suppressed by

Statement

Reference

Pten^UAS.cKa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by DJ-1alpha[+]/DJ-1α^Δ72

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by dj-1β^Δ93/dj-1beta[+]

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by dj-1β^Δ93/dj-1β^Δ93

(Aron et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pten^UAS.cKa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by DJ-1α[+]/DJ-1α^k04204

(Kim et al., 2005)

Suppressed by

Statement

Reference

Pten^UAS.cKa, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Ret^UAS.cLa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has ommatidium phenotype, suppressible | partially by Ret^UAS.cLa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by dj-1β^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has ommatidium phenotype, suppressible | partially by dj-1β^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by DJ-1α^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^ey.PU has ommatidium phenotype, suppressible | partially by DJ-1α^UAS.cMa, Scer\GAL4^ey.PU

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\PARK7^UAS.cKa, Scer\GAL4^GMR.PF

(Kim et al., 2005)

NOT suppressed by

Statement

Reference

Pten^UAS.cKa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by DJ-1alpha[+]/DJ-1α^Δ72

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by dj-1β^Δ93/dj-1beta[+]

(Aron et al., 2010)

Pten^UAS.cKa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by dj-1β^Δ93/dj-1β^Δ93

(Aron et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Ret^Scer\UAS.cLa, dj-1β^Scer\UAS.cMa or DJ-1α^Scer\UAS.cMa significantly partially suppresses the decreases in eye and ommatidial size seen in flies with expression of Pten^Scer\UAS.cKa driven by Scer\GAL4^ey.PU. DJ-1α^Δ72/+, dj-1β^Δ93/+ or dj-1β^Δ93/dj-1β^Δ93 does not suppress the decreases in eye size seen in flies with expression of Pten^Scer\UAS.cKa driven by Scer\GAL4^GMR.PU.

(Aron et al., 2010)

Flies expressing Pten^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF show an increase in roughness and a further slight decrease in eye size if they are also carrying DJ-1α^k04204/+.

(Kim et al., 2005)

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\PARK7^Scer\UAS.cKa suppresses the eye phenotype caused by expression of Pten^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF.

(Kim et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pten^Scer\UAS.cKa

Pten^UAS.cKa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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