FlyBase Allele Report: Dmel\Gcn5[Q186st]

General Information

Symbol

Dmel\Gcn5^Q186st

Species

D. melanogaster

Name

FlyBase ID

FBal0190620

Feature type

allele

Associated gene

Dmel\Gcn5

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Carre et al., 2005)

Mutagen

ethyl methanesulfonate

(Carre et al., 2005)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q186term.

(Carre et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:12,523,348..12,523,348 [-]

Nucleotide change:

C12523348T

Amino acid change:

Q186term | Gcn5-PA

Reported amino acid change:

Q186term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Carre et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | larval stage (with Gcn5^E333st)

(Wang et al., 2020)

lethal (with Df(3L)sex204)

(Carre et al., 2005)

lethal | recessive

(Carre et al., 2005)

lethal - all die before end of prepupal stage (with Gcn5^E333st)

(Carre et al., 2005)

some die during prepupal stage | recessive (with Gcn5^E333st)

(Carre et al., 2005)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage (with Gcn5^E333st)

(Wang et al., 2020)

prepupa (with Gcn5^E333st)

(Carre et al., 2005)

Detailed Description

Statement

Reference

Pcaf^E333st/Pcaf^Q186st animals develop to wandering third instar, but do not form a puparium at the normal time but continue to wander doe an additional 4-5 days. When they eventually stop moving, they fail to evert their spiracles and form abnormally long prepupae. These die with partial separation of the posterior part of the prepupa from the pupal case.

(Carre et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Gcn5^Q186st/Gcn5[+] is a non-suppressor of visible phenotype of Scer\GAL4^Ser.PGF, Sin3A^RNAi.UAS.WIZ

(Swaminathan and Pile, 2010)

Phenotype Manifest In