FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Gcn5
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General Information
Symbol
Dmel\Gcn5
Species
D. melanogaster
Name
Gcn5 acetyltransferase
Annotation Symbol
CG4107
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020388
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dGcn5, Pcaf, KAT, dKAT2, dmGCN5

Key Links
Genomic Location
Cytogenetic map
69C4-69C4
Sequence location
Recombination map
3-38
RefSeq locus
NT_037436 REGION:12521129..12524014
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Guelman et al., 2006)
enables histone acetyltransferase activity
inferred from direct assay
(Guelman et al., 2006)
enables histone H3 acetyltransferase activity
inferred from direct assay
(Suganuma et al., 2008)
enables histone H4 acetyltransferase activity
inferred from direct assay
(Suganuma et al., 2008)
enables protein binding
inferred from physical interaction with UniProtKB:Q7KSD8
(Muratoglu et al., 2003)
inferred from physical interaction with UniProtKB:Q8I8V0
(Muratoglu et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables acyltransferase activity, transferring groups other than amino-acyl groups
inferred from electronic annotation with InterPro:IPR000182
(InterPro Project Members, 2004-)
enables histone acetyltransferase activity
inferred from electronic annotation with InterPro:IPR009464, InterPro:IPR016376, InterPro:IPR037800
(InterPro Project Members, 2004-)
enables histone H3 acetyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN000720593
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in chromatin remodeling
inferred from direct assay
(Suganuma et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in chromatin remodeling
inferred from biological aspect of ancestor with PANTHER:PTN000720593
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000720593
(GO Reference Genome Project, 2011-)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR009464, InterPro:IPR016376
(InterPro Project Members, 2004-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
part_of ATAC complex
inferred from direct assay
(Suganuma et al., 2012, Guelman et al., 2006)
part_of H3 histone acetyltransferase complex
inferred from direct assay
(Torres-Zelada et al., 2019)
located_in nucleus
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006)
located_in polytene chromosome puff
inferred from direct assay
(Ciurciu et al., 2009)
located_in polytene chromosome
inferred from direct assay
(Kusch et al., 2003)
part_of SAGA complex
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of ATAC complex
inferred from biological aspect of ancestor with PANTHER:PTN001111731
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from electronic annotation with InterPro:IPR009464, InterPro:IPR016376
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
histone acetyltransferase activity
RHEA 21992:
Summaries
Gene Snapshot
Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. [Date last reviewed: 2019-08-01]
Gene Group (FlyBase)
ATAC COMPLEX -
The Ada2a-containing (ATAC) complex is a metazoan histone acetyltransferase complex. It positively regulates gene transcription and, although it does not have any intrinsic remodeling activity, facilitates nucleosome sliding of ISWI and SWI-SNF families of chromatin-remodeling complexes. (Adapted from FBrf0204126).
SAGA COMPLEX -
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).
HISTONE ACETYLTRANSFERASES -
Histone acetyltransferases catalyze the acetylation of conserved lysine residues on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyl lysine. (Adapted from PMID:11395403).
ADA COMPLEX -
The Ada2/Gcn5/Ada3 transcription activator (ADA) complex is a Gcn5-containing histone acetyltransferase complex that regulates transcription by acetylating core histones, preferentially histone H3 and nucleosomal substrates. (Adapted from FBrf0242086, FBrf0247978 and FBrf0248705).
CHAT COMPLEX -
The chiffon histone acetyltransferase (CHAT) complex is a unique Gcn5 complex specific to insects that shows characteristic histone acetyltransferase activity towards histone H3. (Adapted from FBrf0241207, FBrf0247978 and FBrf0248705).
Summary (Interactive Fly)

a major histone H3 acetylase in Drosophila that plays a key role in the control of specific morphogenetic cascades during developmental transitions - Gcn5 interacts with Cyclin A to facilitate proper turnover in germ-line stem cells - Gcn5 promotes Cyclin A ubiquitination, which is dependent on its acetylating activity.

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Gcn5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VTZ1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gcn5-RA
FBtr0075969
NM_140329
2770
813
Additional Transcript Data and Comments
Reported size (kB)

2.8 (northern blot)

(Smith et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gcn5-PA
FBpp0075701
92.2
813
9.15
Q9VTZ1
NP_648586
AAF49904
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

813 (aa); 998 (kD observed); 93 (kD predicted)

(Smith et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gcn5 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.45

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
day 1 of adulthood
testis | restricted

Comment: apical tip

(Gan et al., 2010)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Smith et al., 1998)
Additional Descriptive Data

Gcn5 transcript is localized to the apical tip of the adult testis.

(Gan et al., 2010)

Pcaf transcripts are detected throughout development on northern blots with the highest levels in early embryos and late larvae.

(Smith et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of ATAC complex
inferred from direct assay
(Suganuma et al., 2012, Guelman et al., 2006)
part_of H3 histone acetyltransferase complex
inferred from direct assay
(Torres-Zelada et al., 2019)
located_in nucleus
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006)
located_in polytene chromosome puff
inferred from direct assay
(Ciurciu et al., 2009)
located_in polytene chromosome
inferred from direct assay
(Kusch et al., 2003)
part_of SAGA complex
inferred from direct assay
(Weake et al., 2011, Guelman et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gcn5 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gcn5
Transgenic constructs containing regulatory region of Gcn5
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)sex204
(Carre et al., 2005)
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(3L)sex204)
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of prepupal stage (with Gcn5E333st)
lethal - all die before end of prepupal stage (with Gcn5Q186st)
lethal - all die before end of prepupal stage | recessive
lethal - all die before end of pupal stage (with Df(3L)sex204)
partially lethal - majority die (with Gcn5C137Y)
partially lethal - majority die (with Gcn5E333st)
partially lethal - majority die (with Gcn5ΔT280-F285)
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal flight, with Scer\GAL4Mef2.PR
abnormal neurophysiology | larval stage, with Scer\GAL4egr-GAL4
abnormal neurophysiology | larval stage (with Gcn5E333st)
abnormal neurophysiology | larval stage (with Gcn5Q186st)
abnormal size | adult stage, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
abnormal size | larval stage, with Scer\GAL4dome-PG14
abnormal size | larval stage, with Scer\GAL4en-e16E
decreased cell number | adult stage, with Scer\GAL4en-e16E
decreased cell number | progressive, with Scer\GAL4Ugt36A1.PU
flightless, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
flightless (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
increased cell death | larval stage, with Scer\GAL4en-e16E
increased occurrence of cell division | larval stage, with Scer\GAL4en-e16E
some die during larval stage
some die during pharate adult stage (with Gcn5C137Y)
some die during pharate adult stage (with Gcn5E333st)
some die during pharate adult stage (with Gcn5ΔT280-F285)
some die during prepupal stage | recessive
some die during prepupal stage | recessive (with Gcn5E333st)
some die during prepupal stage | recessive (with Gcn5Q186st)
some die during pupal stage
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
visible | adult stage (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
Phenotype manifest in
Allele
adult cuticle & adult abdomen (with Gcn5C137Y)
adult cuticle & adult abdomen (with Gcn5E333st)
adult cuticle & adult abdomen (with Gcn5ΔT280-F285)
adult heart, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
adult heart, with Scer\GAL4tin.PU
adult heart (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
adult heart (with Df(3L)sex204), with Gcn5UAS.Tag:FLAG, Scer\GAL4da.G32
adult pericardial cell, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
adult pericardial cell (with Df(3L)sex204)
adult pericardial cell (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
adult pericardial cell (with Df(3L)sex204), with Gcn5UAS.Tag:FLAG, Scer\GAL4da.G32
adult pericardial cell | progressive, with Scer\GAL4Ugt36A1.PU
cortical zone of lymph gland primary lobe | larval stage, with Scer\GAL4dome-PG14
cuticle & abdomen & pharate adult, with Scer\GAL4NP5153
cuticle & abdomen & pharate adult (with Gcn5C137Y)
cuticle & abdomen & pharate adult (with Gcn5E333st)
cuticle & abdomen & pharate adult (with Gcn5ΔT280-F285)
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4egr-GAL4
embryonic/larval neuromuscular junction | larval stage (with Gcn5E333st)
embryonic/larval neuromuscular junction | larval stage (with Gcn5Q186st)
eye, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
eye (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
eye (with Df(3L)sex204), with Gcn5ΔGcn5.UAS, Scer\GAL4da.G32
eye (with Gcn5C137Y)
eye (with Gcn5E333st)
eye (with Gcn5ΔT280-F285)
eye photoreceptor cell
femur, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
femur (with Df(3L)sex204), with Gcn5ΔGcn5.UAS, Scer\GAL4da.G32
imaginal disc
intestinal stem cell, with Scer\GAL4NP5130
leg, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
leg (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
metathoracic leg (with Gcn5C137Y)
metathoracic leg (with Gcn5E333st)
metathoracic leg (with Gcn5ΔT280-F285)
metathoracic leg | pharate adult stage (with Gcn5C137Y)
metathoracic leg | pharate adult stage (with Gcn5E333st)
metathoracic leg | pharate adult stage (with Gcn5ΔT280-F285)
ommatidium (with Gcn5C137Y)
ommatidium (with Gcn5E333st)
ommatidium (with Gcn5ΔT280-F285)
oocyte | oogenesis stage S5, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
oocyte | oogenesis stage S5 (with Df(3L)sex204), with Gcn5UAS.cCa, Scer\GAL4da.G32
oocyte | oogenesis stage S5 (with Df(3L)sex204), with Gcn5ΔBromo.UAS, Scer\GAL4da.G32
oocyte | oogenesis stage S6, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
oocyte | oogenesis stage S6 (with Df(3L)sex204), with Gcn5UAS.cCa, Scer\GAL4da.G32
oocyte | oogenesis stage S6 (with Df(3L)sex204), with Gcn5ΔBromo.UAS, Scer\GAL4da.G32
ovary, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
ovary (with Df(3L)sex204), with Gcn5UAS.cCa, Scer\GAL4da.G32
ovary (with Df(3L)sex204), with Gcn5ΔBromo.UAS, Scer\GAL4da.G32
polytene chromosome puff | wandering third instar larval stage
prepupa
prepupa (with Gcn5E333st)
prepupa (with Gcn5Q186st)
tarsal segment, with Scer\GAL4vg.boundary
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Df(3L)sex204/Gcn5E333st, Scer\GAL4da.G32
wing (with Df(3L)sex204), with Gcn5F304S.UAS.Tag:FLAG, Scer\GAL4da.G32
wing (with Df(3L)sex204), with Gcn5ΔGcn5.UAS, Scer\GAL4da.G32
wing (with Gcn5C137Y)
wing (with Gcn5E333st)
wing (with Gcn5ΔT280-F285)
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc posterior compartment, with Scer\GAL4en-e16E
wing margin, with Scer\GAL4vg.boundary
wing vein, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\KAT2A
13 of 14
Yes
Yes
1  
Hsap\KAT2B
12 of 14
No
Yes
1  
Hsap\BAZ2A
2 of 14
No
No
Hsap\BPTF
2 of 14
No
No
Hsap\BRD3
2 of 14
No
No
Hsap\BRD4
2 of 14
No
No
1  
Hsap\BRD8
2 of 14
No
No
Hsap\BRDT
2 of 14
No
No
Hsap\EP300
2 of 14
No
No
Hsap\PBRM1
2 of 14
No
No
Hsap\BAZ1A
1 of 14
No
No
Hsap\BAZ1B
1 of 14
No
No
Hsap\BAZ2B
1 of 14
No
No
Hsap\BRD2
1 of 14
No
No
2  
Hsap\BRPF1
1 of 14
No
No
Hsap\BRWD1
1 of 14
No
No
Hsap\CECR2
1 of 14
No
No
Hsap\CREBBP
1 of 14
No
No
Hsap\PHIP
1 of 14
No
No
Hsap\TRIM24
1 of 14
No
No
Hsap\TRIM66
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (17)
Rnor\Kat2a
13 of 14
Yes
Yes
Rnor\Kat2b
4 of 14
No
Yes
Rnor\Brd3
2 of 14
No
No
Rnor\Brd4
2 of 14
No
No
Rnor\Brd8
2 of 14
No
No
Rnor\Cecr2
2 of 14
No
No
Rnor\Pbrm1
2 of 14
No
No
Rnor\Baz1a
1 of 14
No
No
Rnor\Baz1b
1 of 14
No
No
Rnor\Bptf
1 of 14
No
No
Rnor\Brd2
1 of 14
No
No
Rnor\Brd9
1 of 14
No
No
Rnor\Brdt
1 of 14
No
No
Rnor\Brpf1
1 of 14
No
No
Rnor\Crebbp
1 of 14
No
No
Rnor\Phip
1 of 14
No
No
Rnor\Trim66
1 of 14
No
No
Mus musculus (laboratory mouse) (22)
Mmus\Kat2a
12 of 14
Yes
Yes
Mmus\Kat2b
12 of 14
Yes
Yes
Mmus\Baz2a
2 of 14
No
No
Mmus\Bptf
2 of 14
No
No
Mmus\Brd2
2 of 14
No
No
Mmus\Brd3
2 of 14
No
No
Mmus\Brd4
2 of 14
No
No
Mmus\Brd8dc
2 of 14
No
No
Mmus\Brd8
2 of 14
No
No
Mmus\Brdt
2 of 14
No
No
Mmus\Cecr2
2 of 14
No
No
Mmus\Pbrm1
2 of 14
No
No
Mmus\Baz1b
1 of 14
No
No
Mmus\Baz2b
1 of 14
No
No
Mmus\Brd9
1 of 14
No
No
Mmus\Brpf1
1 of 14
No
No
Mmus\Brwd1
1 of 14
No
No
Mmus\Crebbp
1 of 14
No
No
Mmus\Ep300
1 of 14
No
No
Mmus\Phip
1 of 14
No
No
Mmus\Trim24
1 of 14
No
No
Mmus\Trim66
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\kat2a
11 of 13
Yes
Yes
Xtro\kat2b
10 of 13
No
Yes
Xtro\baz2b
1 of 13
No
No
Xtro\brd2
1 of 13
No
No
Xtro\brd8
1 of 13
No
No
Xtro\brdt
1 of 13
No
No
Xtro\brpf1
1 of 13
No
No
Xtro\brwd3
1 of 13
No
No
Xtro\cecr2
1 of 13
No
No
Xtro\kdm6a
1 of 13
No
No
Xtro\kri1
1 of 13
No
No
Xtro\myo9b
1 of 13
No
Yes
Xtro\phf5a
1 of 13
No
No
Xtro\ppp2r3b
1 of 13
No
No
Xtro\st18
1 of 13
No
No
Xtro\trim24
1 of 13
No
No
Xtro\trim33
1 of 13
No
No
Xtro\tspan2
1 of 13
No
No
Danio rerio (Zebrafish) (21)
Drer\kat2a
12 of 14
Yes
Yes
Drer\kat2b
12 of 14
Yes
Yes
Drer\baz1a
2 of 14
No
No
Drer\bptf
2 of 14
No
No
Drer\brd2a
2 of 14
No
No
Drer\brd3a
2 of 14
No
No
Drer\brd4
2 of 14
No
No
Drer\brd8a
2 of 14
No
No
Drer\brd8b
2 of 14
No
No
Drer\brdt
2 of 14
No
No
Drer\cecr2
2 of 14
No
No
Drer\pbrm1l
2 of 14
No
No
Drer\baz1b
1 of 14
No
No
Drer\baz2a
1 of 14
No
No
Drer\baz2ba
1 of 14
No
No
Drer\brd2b
1 of 14
No
No
Drer\brd3b
1 of 14
No
No
Drer\brd7
1 of 14
No
No
Drer\crebbpa
1 of 14
No
No
Drer\ep300b
1 of 14
No
No
Drer\pbrm1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\pcaf-1
13 of 14
Yes
Yes
Cele\athp-2
2 of 14
No
No
Cele\baz-2
1 of 14
No
No
Cele\C29F9.5
1 of 14
No
No
Cele\C29F9.6
1 of 14
No
No
Cele\C49F5.5
1 of 14
No
No
Cele\cbp-1
1 of 14
No
No
Cele\cbp-2
1 of 14
No
No
Cele\cbp-3
1 of 14
No
No
Cele\F13C5.2
1 of 14
No
No
Cele\F22F1.3
1 of 14
No
Yes
Cele\pbrm-1
1 of 14
No
No
Cele\sepa-1
1 of 14
No
Yes
Cele\ZK1010.10
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (11)
Agam\AgaP_AGAP004434
12 of 12
Yes
Yes
Agam\AgaP_AGAP001099
2 of 12
No
No
Agam\AgaP_AGAP003845
2 of 12
No
No
Agam\AgaP_AGAP005187
2 of 12
No
No
Agam\AgaP_AGAP000029
1 of 12
No
No
Agam\AgaP_AGAP000668
1 of 12
No
No
Agam\AgaP_AGAP002807
1 of 12
No
No
Agam\AgaP_AGAP003882
1 of 12
No
No
Agam\AgaP_AGAP005186
1 of 12
No
No
Agam\AgaP_AGAP006133
1 of 12
No
No
Agam\AgaP_AGAP008017
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (30)
Atha\HAG1
10 of 13
Yes
Yes
Atha\BET10
2 of 13
No
No
Atha\GTE3
2 of 13
No
No
Atha\GTE6
2 of 13
No
No
Atha\GTE7
2 of 13
No
No
Atha\IMB1
2 of 13
No
No
Atha\NPX1
2 of 13
No
No
Atha\AT1G16705
1 of 13
No
No
Atha\AT1G17790
1 of 13
No
No
Atha\AT1G20670
1 of 13
No
No
Atha\AT1G58025
1 of 13
No
No
Atha\AT1G76380
1 of 13
No
No
Atha\AT4G16215
1 of 13
No
Yes
Atha\AT5G08630
1 of 13
No
No
Atha\AT5G46550
1 of 13
No
No
Atha\AT5G55040
1 of 13
No
No
Atha\BET9
1 of 13
No
No
Atha\BT1
1 of 13
No
Yes
Atha\BT2
1 of 13
No
Yes
Atha\BT3
1 of 13
No
No
Atha\BT4
1 of 13
No
Yes
Atha\BT5
1 of 13
No
Yes
Atha\GTE2
1 of 13
No
No
Atha\GTE4
1 of 13
No
No
Atha\GTE8
1 of 13
No
No
Atha\HAC1
1 of 13
No
No
Atha\HAC2
1 of 13
No
No
Atha\HAC4
1 of 13
No
No
Atha\HAC5
1 of 13
No
No
Atha\HAC12
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\GCN5
10 of 13
Yes
Yes
1  
Scer\BDF1
2 of 13
No
No
Scer\BDF2
2 of 13
No
No
Scer\SPT7
2 of 13
No
Yes
Scer\ITC1
1 of 13
No
No
Scer\RSC1
1 of 13
No
No
Scer\RSC2
1 of 13
No
No
Scer\RSC4
1 of 13
No
No
Scer\YPL216W
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\gcn5
9 of 12
Yes
Yes
Spom\bdf1
2 of 12
No
No
Spom\spt7
2 of 12
No
Yes
Spom\bdc1
1 of 12
No
No
Spom\rsc1
1 of 12
No
No
Spom\rsc4
1 of 12
No
No
Spom\SPAC631.02
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gcn5. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (13)
Acf
3 of 13
tbrd-1
3 of 13
Brd8
2 of 13
E(bx)
2 of 13
fs(1)h
2 of 13
tbrd-3
2 of 13
tou
2 of 13
dikar
1 of 13
Lpt
1 of 13
nej
1 of 13
polybromo
1 of 13
Taf1
1 of 13
tbrd-2
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 3 )
Allele
Disease
Interaction
References
Gcn5E333st
exacerbates  Huntington's disease
modeled by Hsap\HTTQ93.ex1.UAS
(Bodai et al., 2012)
Gcn5RNAi.UAS
ameliorates  tauopathy
modeled by Hsap\MAPTUAS.wt
(Wang et al., 2020)
Gcn5UAS.cBa
DOES NOT ameliorate  Huntington's disease
modeled by Hsap\HTTQ93.ex1.UAS
(Bodai et al., 2012)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
KAT2A; lysine acetyltransferase 2A
13 of 14
LYSINE ACETYLTRANSFERASE 2A; KAT2A
       
      KAT2B; lysine acetyltransferase 2B
      12 of 14
      LYSINE ACETYLTRANSFERASE 2B; KAT2B
           
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Gcn5 - Ada1-2
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Weake et al., 2009)
          Gcn5 - Ada2a
          anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving, ion exchange chromatography, western blot, two hybrid, anti bait coimmunoprecipitation
          (Suganuma et al., 2012, Suganuma et al., 2010, Suganuma et al., 2008, Ciurciu et al., 2006, Guelman et al., 2006, Lebedeva et al., 2004, Kusch et al., 2003, Muratoglu et al., 2003)
          Gcn5 - Ada2b
          affinity chromatography technology, molecular sieving, western blot, anti bait coimmunoprecipitation, pull down, autoradiography, multidimensional protein identification technology, ion exchange chromatography, anti tag coimmunoprecipitation, two hybrid, peptide massfingerprinting, anti tag western blot
          (Soffers et al., 2019, Torres-Zelada et al., 2019, Popova et al., 2018, Weake et al., 2011, Kurshakova et al., 2009, Weake et al., 2009, Weake et al., 2008, Kurshakova et al., 2007, Ciurciu et al., 2006, Guelman et al., 2006, Lebedeva et al., 2004, Qi et al., 2004, Kusch et al., 2003, Muratoglu et al., 2003)
          Gcn5 - Ada3
          experimental knowledge based, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
          (Guruharsha et al., 2011, Weake et al., 2009, Guelman et al., 2006)
          Gcn5 - Atac1
          anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, western blot, anti bait coimmunoprecipitation
          (Guruharsha et al., 2011, Guelman et al., 2006)
          Gcn5 - Atac2
          molecular sieving, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
          (Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)
          Gcn5 - Atxn7
          anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
          (Mohan et al., 2014)
          Gcn5 - Brf
          anti bait coimmunoprecipitation, western blot
          (Popova et al., 2018)
          Gcn5 - CG9890
          anti bait coimmunoprecipitation, western blot
          (Fursova et al., 2018)
          Gcn5 - Chrac-14
          experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
          (Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)
          Gcn5 - Cp190
          anti bait coimmunoprecipitation, western blot
          (Ali et al., 2017)
          Gcn5 - CycA
          anti tag coimmunoprecipitation, anti tag western blot
          (Liu et al., 2017)
          Gcn5 - D12
          molecular sieving, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
          (Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)
          Gcn5 - Hcf
          experimental knowledge based, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
          (Guruharsha et al., 2011, Guelman et al., 2006)
          Gcn5 - Jra
          anti bait coimmunoprecipitation, anti tag western blot, pull down, autoradiography
          (Kim et al., 2005)
          Gcn5 - MBD-R2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gcn5 - Mocs2B
          anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, molecular sieving, experimental knowledge based
          (Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)
          Gcn5 - NC2β
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gcn5 - Nipped-A
          anti bait coimmunoprecipitation, western blot
          (Popova et al., 2018, Kurshakova et al., 2009, Kurshakova et al., 2007, Kusch et al., 2003)
          Gcn5 - Pbp45
          anti bait coimmunoprecipitation, western blot
          (Popova et al., 2018)
          Gcn5 - PolE4
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gcn5 - Rcd1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gcn5 - ReepA
          experimental knowledge based
          (Guruharsha et al., 2011)
          Gcn5 - Rel
          anti bait coimmunoprecipitation, anti tag western blot, pull down, autoradiography
          (Kim et al., 2005)
          Gcn5 - Saf6
          anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
          (Soffers et al., 2021, Weake et al., 2009)
          Gcn5 - Sf3b5
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Stegeman et al., 2016)
          Gcn5 - Sgf11
          anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
          (Gurskiy et al., 2012, Weake et al., 2008)
          Gcn5 - Sgf29
          anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
          (Guruharsha et al., 2011, Weake et al., 2009)
          Gcn5 - Spt20
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Stegeman et al., 2016)
          Gcn5 - Spt3
          anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot
          (Stegeman et al., 2016, Guelman et al., 2006, Kusch et al., 2003)
          Gcn5 - Taf10
          anti bait coimmunoprecipitation, western blot
          (Kurshakova et al., 2009, Kurshakova et al., 2007, Lebedeva et al., 2004, Muratoglu et al., 2003, Georgieva et al., 2001)
          Gcn5 - Taf10b
          anti bait coimmunoprecipitation, western blot
          (Muratoglu et al., 2003)
          Gcn5 - Taf4
          ion exchange chromatography, molecular sieving, western blot
          (Muratoglu et al., 2003)
          Gcn5 - Taf9
          ion exchange chromatography, molecular sieving, western blot
          (Muratoglu et al., 2003)
          Gcn5 - Tbp
          anti bait coimmunoprecipitation, western blot
          (Soffers et al., 2021)
          Gcn5 - chif
          two hybrid, anti tag coimmunoprecipitation, anti tag western blot, western blot, multidimensional protein identification technology, pull down
          (George et al., 2022, Torres-Zelada et al., 2019)
          Gcn5 - e(y)2
          anti bait coimmunoprecipitation, western blot
          (Gurskiy et al., 2012, Gurskiy et al., 2010, Kopytova et al., 2010, Kurshakova et al., 2009, Kurshakova et al., 2007)
          Gcn5 - kay
          pull down, autoradiography
          (Kim et al., 2005)
          Gcn5 - not
          anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
          (Mohan et al., 2014, Gurskiy et al., 2012, Weake et al., 2008)
          Gcn5 - p53
          pull down, western blot, anti bait coimmunoprecipitation
          (Kusch et al., 2003)
          Gcn5 - su(Hw)
          anti bait coimmunoprecipitation, western blot
          (Vorobyeva et al., 2013)
          Gcn5 - wda
          anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
          (Weake et al., 2009)
          Gcn5 - wds
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Suganuma et al., 2010, Suganuma et al., 2008)
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Gcn5
          enhanceable
          hts
          (Gonçalves et al., 2018)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          dom
          enhanceable
          Gcn5
          (Ellis et al., 2015)
          hts
          enhanceable
          Gcn5
          (Gonçalves et al., 2018)
          Myc
          suppressible
          Gcn5
          (Furrer et al., 2010, Secombe et al., 2007)
          Sin3A
          suppressible
          Gcn5
          (Swaminathan and Pile, 2010)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-38
          Cytogenetic map
          69C4-69C4
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          69C4-69C4
          Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          69C8-69C12
          (Smith, 1997.10.14)
          69C8-69C12
          (determined by in situ hybridisation)
          (Smith et al., 1998, Smith et al., 1997)
          Experimentally Determined Recombination Data
          Location

          3-38

          (FlyBase, 2016)

          3-32.6

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (17)
          Genomic Clones (11)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (89)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Ali et al., 2017, Vorobyeva et al., 2013, Kusch et al., 2003, Muratoglu et al., 2003, Smith et al., 1998)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                DNA-protein interactions: genome-wide binding profile assayed for Pcaf protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

                (Filion et al., 2010)

                dsRNA has been made from templates generated with primers directed against this gene.

                (Marr et al., 2006)

                dsRNA has been made from templates generated with primers directed against this gene. RNAi of Pcaf causes an increase in lateral branching and a marked reduction in dorsal extension of ddaE neurons. RNAi also causes defects in muscle and defects in dendrite morphogenesis.

                (Parrish et al., 2006)

                Cloned by degenerate PCR using primers designed from human and yeast homologs.

                (Smith et al., 1998)
                Relationship to Other Genes
                Source for database merge of
                Additional comments

                Relationship of "Pcaf" to "HatB" unclear.

                (Smith, 1997.10.14)
                Nomenclature History
                Source for database identify of

                Source for identity of: Pcaf CG4107

                (Bayraktaroglu, 1999.11)

                Source for identity of: Gcn5 Pcaf

                (FlyBase, 2009-)
                Nomenclature comments

                "Pcaf" renamed to "Gcn5" to reflect overwhelming usage in the literature and the symbol used in the first research paper to characterize the gene (FBrf0103041).

                (FlyBase, 2009-)
                Etymology
                Synonyms and Secondary IDs (25)
                Reported As
                Symbol Synonym
                Ada4
                (Guelman et al., 2006)
                CG4107
                (Schwartz et al., 2016, Stegeman et al., 2016, Hosono et al., 2015, Mohan et al., 2014, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Ardehali et al., 2009, Keleman et al., 2009.8.5, Weake et al., 2009, Gandhi et al., 2007, Ramet et al., 2002)
                GCN5
                (Vorobyeva et al., 2025, Wu et al., 2023, Fursova et al., 2020, Fursova et al., 2018, Yan et al., 2018, Hirano et al., 2016, Vorobyeva et al., 2013, Dunlap et al., 2012, Furrer et al., 2010, Kopytova et al., 2010, Orlova et al., 2010, Ciurciu et al., 2009, Kurshakova et al., 2009, Tie et al., 2009, Vorobyeva et al., 2009, Vorobyeva et al., 2008, Ferreira et al., 2007, Lebedeva et al., 2007, Marr et al., 2006, Lebedeva, 2005, Lebedeva et al., 2005, Pankotai et al., 2005, Yang, 2004, Boucher et al., 2001)
                Gcn5
                (Pan et al., 2025, Gera et al., 2024, Li et al., 2024, Murthy et al., 2024, Tang et al., 2024, Willnow and Teleman, 2024, Escobedo et al., 2023, Krasnov et al., 2023, Liu et al., 2023, Ding et al., 2022, Ecovoiu et al., 2022, Faragó et al., 2022, Miao et al., 2022, Cornelio-Parra et al., 2021, Helmlinger et al., 2021, Makki and Meller, 2021, Torres-Zelada and Weake, 2021, Vorobyeva et al., 2021, Mahesh et al., 2020, Cloud et al., 2019, Neves and Eisenman, 2019, Soffers et al., 2019, Gene Disruption Project members, 2018-, Gonçalves et al., 2018, McCarthy et al., 2018, Popova et al., 2018, Ali et al., 2017, Liu et al., 2017, Mazina et al., 2017, Transgenic RNAi Project members, 2017-, Stegeman et al., 2016, Mohan et al., 2014, Ma et al., 2013, Gurskiy et al., 2012, Spedale et al., 2012, Suganuma et al., 2012, Weake et al., 2011, Gurskiy et al., 2010, Suganuma et al., 2010, Ardehali et al., 2009, Rodriguez-Navarro, 2009, Weake et al., 2009, Carré et al., 2008, Grau et al., 2008, Hsu et al., 2008, Martinez and Arnosti, 2008, Suganuma et al., 2008, Gause et al., 2006, Guelman et al., 2006, Carre et al., 2005, Dai and Mannervik, 2003, Di Croce et al., 1999, Smith, 1997.10.14)
                Gcn5/PCAF
                (Aoyagi and Wassarman, 2000)
                Gcn5/Pcaf
                (Guelman et al., 2006)
                KAT
                (Suganuma et al., 2010, Swaminathan et al., 2010)
                KAT2
                (Suganuma et al., 2012)
                P/CAF
                (Carre et al., 2004)
                PCAF
                (Ellis et al., 2015, Filion et al., 2010, Swaminathan and Pile, 2010, Ma, 2005, Kuo and Allis, 1998)
                Pcaf
                (Neumüller et al., 2013, Bodai et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kirilly et al., 2011, Zhou et al., 2011, Gan et al., 2010, Swaminathan and Pile, 2010, Swaminathan et al., 2010, Ayroles et al., 2009, Southall and Brand, 2009, Tie et al., 2009, Secombe et al., 2007, Parrish et al., 2006)
                anon-WO0172774.89
                dGCN5
                (Endo et al., 2021, Shimaji et al., 2019, Crump et al., 2011, Nagy et al., 2010, Kurshakova et al., 2007, Lebedeva et al., 2004, Muratoglu et al., 2003, Georgieva et al., 2001, Park et al., 2001, Smith et al., 1998)
                dGCN5 HAT
                (Georgieva et al., 2000)
                dGcn5
                (Wang et al., 2020, Spedale et al., 2012, Vamos and Boros, 2012, Kirilly et al., 2011, Swaminathan and Pile, 2010, Ciurciu et al., 2008, Grau et al., 2008, Weake et al., 2008, Jacquier et al., 2007, Ciurciu et al., 2006, Guelman et al., 2006, Carre et al., 2005, Carre et al., 2005, Qi et al., 2004, Guelman et al., 2003, Kusch et al., 2003, Kusch et al., 2003, Muratoglu et al., 2003)
                dGcn5i
                (Ma et al., 2013)
                dKAT2
                (Crump et al., 2011, Weake et al., 2008)
                dPCAF
                (Smith et al., 1997)
                dmGCN5
                (Lebedeva, 2005, Lebedeva et al., 2005)
                dmHAG401
                (Pandey et al., 2002)
                gcn5
                (Li et al., 2023, Badmos et al., 2021, Regadas et al., 2021, Janssens et al., 2017, Rao et al., 2015, Bodai et al., 2012, Weake et al., 2008, Guelman et al., 2003)
                p/CAF
                (Di Croce et al., 1999)
                pCAF
                (L Black et al., 2016, Petruk et al., 2013)
                Name Synonyms
                Gcn5 acetyltransferase
                Gcn5 ortholog
                Pcaf
                Secondary FlyBase IDs
                • FBgn0046345
                Datasets (1)
                Study focus (1)
                Experimental Role
                Project
                Project Type
                Title
                • transgene_used
                FBGSE22069
                Protein profiling reveals five principal chromatin types in Drosophila cells.
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 54 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (192)