FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\locoP452
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General Information
Symbol
Dmel\locoP452
Species
D. melanogaster
Name
FlyBase ID
FBal0190826
Feature type
allele
Associated gene
Dmel\loco
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Yu et al., 2005)
Progenitor genotype
locoEY04589
(Yu et al., 2005)
Cytology
Description

Imprecise excision of locoEY04589 generates locoP283, in which nucleotides -310 to +1277 of the transcript (start point of loco-c1 transcript is +1) are deleted, removing up to and including the region encoding the RGS domain.

(Yu et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A significant decrease in glia number is seen in locoP452 homozygous mutants.

      locoP452 heterozygous larval brains exhibit a wild-type glial number.

      (Kaplow et al., 2008)

      locoP452 homozygotes are viable and display severe locomotion defects.

      (Yu et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      loco[+]/locoP452 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of fzre6

      (Kaplow et al., 2008)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      loco[+]/locoP452 is a suppressor of glial cell | ectopic | third instar larval stage phenotype of fzre6

      (Kaplow et al., 2008)

      loco[+]/locoP452 is a suppressor of subperineurial glial cell | ectopic | third instar larval stage phenotype of fzre6

      (Kaplow et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A locoP452 heterozygous background is able to suppress the rape6 increased glial number phenotype.

      (Kaplow et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      locoP452
      (Kaplow et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)