FlyBase Allele Report: Dmel\Mef2[66-25]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Mef2^66-25

General Information

Symbol

Dmel\Mef2^66-25

Species

D. melanogaster

Name

FlyBase ID

FBal0192078

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lovato et al., 2009)

Mutagen

Progenitor genotype

Cytology

Description

79bp deletion in the ninth intron, removing the splice acceptor site of exon 10. This results in readthrough into the ninth intron during transcription and cryptic splicing into the 10th exon. The resulting protein is truncated due to the readthrough producing a stop codon 1 amino acid after the 9th exon, and it also contains an insertion of a Ser residue after codon 209.

(Lovato et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Mef2^22-21)

(Baker et al., 2005)

lethal (with Mef2^22-24)

(Baker et al., 2005)

lethal (with Mef2^25-34)

(Baker et al., 2005)

lethal (with Mef2^25-42)

(Baker et al., 2005)

lethal (with Mef2^26-6)

(Baker et al., 2005)

lethal (with Mef2^26-7)

(Baker et al., 2005)

lethal (with Mef2^26-49)

(Baker et al., 2005)

lethal (with Mef2^44-5)

(Baker et al., 2005)

lethal (with Mef2^48-7)

(Baker et al., 2005)

lethal (with Mef2^78-11)

(Baker et al., 2005)

lethal | recessive

(Baker et al., 2005)

partially lethal (with Mef2^30-5)

(Baker et al., 2005)

partially lethal (with Mef2^55-5)

(Baker et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

(Baker et al., 2005)

(Baker et al., 2005)

Fails to complement

(Baker et al., 2005)

(Baker et al., 2005)

(Baker et al., 2005)

(Baker et al., 2005)

(Baker et al., 2005)

(Baker et al., 2005)

(Baker et al., 2005)

(Baker et al., 2005)

(Baker et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

66-25

(Lovato et al., 2009)

Mef2^66-25

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections