FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\EkarMB00001
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General Information
Symbol
Dmel\EkarMB00001
Species
D. melanogaster
Name
FlyBase ID
FBal0192531
Feature type
allele
Associated gene
Dmel\Ekar
Associated Insertion(s)
Mi{ET1}EkarMB00001
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Hu et al., 2015)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}EkarMB00001
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Intracellular recordings reveal that light-induced depolarization of photoreceptors is significantly reduced in EkarMB00001 mutant flies compared with wild-type flies, though EM images reveal normal rhabdomere structures in these mutants.

        EM images reveal normal rhabdomere structure in 14-day-old EkarMB00001 mutant flies raised under regular light cycles (12 h light/12 h dark) or in constant darkness.

        10 Lux light stimulation evokes a a significantly reduced depolarization in EkarMB00001 mutant photoreceptors, compared to wild type.

        With low, but not high-intensity moving light patterns EkarMB00001 flies exhibit a reduced ability to track moving patterns.

        (Hu et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        EkarMB00001 is a suppressor | partially of abnormal neurophysiology phenotype of Ihf03355

        (Hu et al., 2015)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG9935MB00001
        (Bellen, 2006.9.1)
        EkarMB00001
        MB00001
        (Hu et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)