FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GclcUAS.cOa
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General Information
Symbol
Dmel\GclcUAS.cOa
Species
D. melanogaster
Name
FlyBase ID
FBal0193058
Feature type
allele
Associated gene
Dmel\Gclc
Associated Insertion(s)
Carried in Construct
P{UAS-Gclc.O}
Also Known As
UAS-Gclc
Key Links
Transgenic product class
cDNA
(Orr et al., 2005)
wild_type
(Orr et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Orr et al., 2005)
wild_type
(Orr et al., 2005)
Mutagen
in vitro construct
(Orr et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Gclc.O}
Cytology
Description

UASt sequences control expression of Gclc cDNA (EcoRI-BamHI fragment from AT05811) consisting of the entire ORF (2157 bp) along with 42 bp of 5'UTR and 374 bp of 3' UTR.

(Orr et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gclc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.lexAop
      (Stapper and Jahn, 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GclcScer\UAS.cOa; Scer\GAL4αTub84B.PL animals are not significantly longer lived than wild-type. However, GclcScer\UAS.cOa; Scer\GAL4D42 and GclcScer\UAS.cOa; Scer\GAL4Appl.G1a animals show significant increases in both mean and maximum life spans (90% mortality) compared to wild-type. These flies also show increased resistance to hydrogen peroxide and paraquat at 40 days old (although not at 10 days old). Significantly increased average lifespan is also seen in GclcScer\UAS.cOa; Scer\GAL4elav-C155 animals (note - this is not seen with all GclcScer\UAS.cOa insertions: P{UAS-Gclc.O}3 and P{UAS-Gclc.O}5 show the effect whereas with P{UAS-Gclc.O}6 lifespan is no different to wild-type.) Increases in lifespan in these flies do not correlate with any changes in respiratory rate.

      (Orr et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      GclcUAS.cOa/Scer\GAL4ppk.PU is a non-suppressor of abnormal neuroanatomy | P-stage phenotype of cnc1223

      (Chew et al., 2021)
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GclcScer\UAS.cOa
      GclcUAS.cOa
      Name Synonyms
      Secondary FlyBase IDs
        References (7)