FlyBase Allele Report: Dmel\cnc[1223]

General Information

Symbol

Dmel\cnc¹²²³

Species

D. melanogaster

Name

FlyBase ID

FBal0369340

Feature type

allele

Associated gene

Dmel\cnc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Chew et al., 2021)

Mutagen

ethyl methanesulfonate

(Chew et al., 2021)

Progenitor genotype

Cytology

Description

Amino acid replacement: W200term.

(Chew et al., 2021)

Contains a nonsense mutation in the specific coding region of the cnc-C isoform.

(Chew et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:23,218,309..23,218,309 [-]

Nucleotide change:

G23218309A

Amino acid change:

W200term | cnc-PC; W200term | cnc-PJ; W200term | cnc-PK; W200term | cnc-PO

Reported amino acid change:

W200term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Chew et al., 2021)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage | somatic clone

(Chew et al., 2021)

Phenotype Manifest In

dendrite | P-stage | somatic clone

(Chew et al., 2021)

larval multidendritic class IV neuron | larval stage | somatic clone

(Chew et al., 2021)

larval multidendritic class IV neuron | P-stage | somatic clone

(Chew et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

cnc¹²²³ has abnormal neuroanatomy | P-stage | somatic clone phenotype, enhanceable by Keap1^UAS.Tag:HA/Scer\GAL4^ppk.PU

(Chew et al., 2021)

NOT suppressed by

Statement

Reference

cnc¹²²³ has abnormal neuroanatomy | P-stage phenotype, non-suppressible by Scer\GAL4^ppk.PU/Sod1^UAS.cWa

(Chew et al., 2021)

cnc¹²²³ has abnormal neuroanatomy | P-stage phenotype, non-suppressible by Scer\GAL4^ppk.PU/Gclm^UAS.cOa

(Chew et al., 2021)

cnc¹²²³ has abnormal neuroanatomy | P-stage phenotype, non-suppressible by Gclc^UAS.cOa/Scer\GAL4^ppk.PU

(Chew et al., 2021)

Enhancer of

Statement

Reference

cnc¹²²³ is an enhancer of abnormal neuroanatomy | P-stage phenotype of Atg8a^HMS06041, Scer\GAL4^ppk.PU

(Tan et al., 2024)

cnc¹²²³/cnc¹²²³ is an enhancer of abnormal neuroanatomy | P-stage phenotype of Keap1^UAS.Tag:HA, Scer\GAL4^ppk.PU

(Chew et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

cnc¹²²³ has dendrite | P-stage | somatic clone phenotype, enhanceable by Keap1^UAS.Tag:HA/Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³ has larval multidendritic class IV neuron | P-stage | somatic clone phenotype, enhanceable by Keap1^UAS.Tag:HA/Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³ has larval multidendritic class IV neuron | larval stage | somatic clone phenotype, enhanceable by Keap1^UAS.Tag:HA/Scer\GAL4^ppk.PU

(Chew et al., 2021)

NOT suppressed by

Statement

Reference

cnc¹²²³ has dendrite | P-stage phenotype, non-suppressible by Scer\GAL4^ppk.PU/Sod1^UAS.cWa

(Chew et al., 2021)

cnc¹²²³ has larval multidendritic class IV neuron | somatic clone | P-stage phenotype, non-suppressible by Scer\GAL4^ppk.PU/Sod1^UAS.cWa

(Chew et al., 2021)

cnc¹²²³ has dendrite | P-stage phenotype, non-suppressible by Scer\GAL4^ppk.PU/Gclm^UAS.cOa

(Chew et al., 2021)

cnc¹²²³ has dendrite | P-stage phenotype, non-suppressible by Gclc^UAS.cOa/Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³ has larval multidendritic class IV neuron | somatic clone | P-stage phenotype, non-suppressible by Gclc^UAS.cOa/Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³ has larval multidendritic class IV neuron | somatic clone | P-stage phenotype, non-suppressible by Scer\GAL4^ppk.PU/Gclm^UAS.cOa

(Chew et al., 2021)

Enhancer of

Statement

Reference

cnc¹²²³ is an enhancer of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Atg8a^HMS06041, Scer\GAL4^ppk.PU

(Tan et al., 2024)

cnc¹²²³ is an enhancer of dendrite | P-stage phenotype of Atg8a^HMS06041, Scer\GAL4^ppk.PU

(Tan et al., 2024)

cnc¹²²³/cnc¹²²³ is an enhancer of dendrite | P-stage phenotype of Keap1^UAS.Tag:HA, Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³/cnc¹²²³ is an enhancer of larval multidendritic class IV neuron | P-stage phenotype of Keap1^UAS.Tag:HA, Scer\GAL4^ppk.PU

(Chew et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cnc^K6

(Chew et al., 2021)

cnc^VL110

(Chew et al., 2021)

Rescued by

cnc¹²²³ is rescued by Scer\GAL4^ppk.PU/cnc^{ΔDLG+ETGE.C.UAS}

(Chew et al., 2021)

cnc¹²²³ is rescued by Scer\GAL4^ppk.PU/cnc^UAS.cSa

(Chew et al., 2021)

Not rescued by

cnc¹²²³ is not rescued by Scer\GAL4^ppk.PU/cnc^ΔA.C.UAS

(Chew et al., 2021)

cnc¹²²³ is not rescued by cnc^ΔB.C.UAS/Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³ is not rescued by cnc^ΔNLS.C.UAS/Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³ is not rescued by cnc^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^ppk.PU

(Chew et al., 2021)

cnc¹²²³ is not rescued by Scer\GAL4^ppk.PU/cnc^UAS.cVa

(Chew et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CNC^Δ

(Wang et al., 2023)

Cnc¹²²³

(Wang et al., 2023)

cnc¹²²³

(Tan et al., 2024, Chew et al., 2021)

l(3)1223

(Chew et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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