FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GclmUAS.cOa
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General Information
Symbol
Dmel\GclmUAS.cOa
Species
D. melanogaster
Name
FlyBase ID
FBal0193059
Feature type
allele
Associated gene
Dmel\Gclm
Associated Insertion(s)
Carried in Construct
P{UAS-Gclm.O}
Also Known As
UAS-Gclm
Key Links
Transgenic product class
cDNA
(Orr et al., 2005)
wild_type
(Orr et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Orr et al., 2005)
wild_type
(Orr et al., 2005)
Mutagen
in vitro construct
(Orr et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Gclm.O}
Cytology
Description

UASt sequences control expression of Gclm cDNA (EcoRI-XhoI fragment from GH01757) consisting of the entire ORF (857 bp) along with 77 bp of 5'UTR and 202 bp of 3' UTR.

(Orr et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Gclm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cTa
      (Trinh et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GclmScer\UAS.cOa; Scer\GAL4D42 and GclmScer\UAS.cOa; Scer\GAL4Appl.G1a animals are not significantly longer lived than wild-type.

      (Orr et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4ppk.PU/GclmUAS.cOa is a non-suppressor of abnormal neuroanatomy | P-stage phenotype of cnc1223

      (Chew et al., 2021)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of GclmScer\UAS.cOa completely rescues the neuronal loss induced by Hsap\SNCAScer\UAS.cTa expression in 20- and 30-day old flies.

      (Trinh et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GclmScer\UAS.cOa
      GclmUAS.cOa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)