FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.
mitochondrial crista & indirect flight muscle
myofibril & indirect flight muscle
In mutant adult flight muscles, the mitochondria are enlarged (being elongated in shape) and fewer in number compared to wild type and they have disrupted cristae.
Mutant cells contain fewer mitochondria per cell than wild type.
Mutants are completely male sterile and almost completely female sterile.
Spermatid nuclei appear normal in mutant males, however the Nebenkern are vacuolated in onion stage spermatids and this vacuolation persists during subsequent spermatid elongation. Numerous defects are seen during individualisation in the mutant testes; the overall architecture of the mutant cysts is disorganised (although the number of spermatids in each cyst, the shape and size of the axoneme and the spatial relationship between the axoneme and mitochondria is normal), the mitochondria are of variable size and often smaller than normal and the cysts often contain a large mass of electron-dense material, which may represent abnormal mitochondria.
Mutants have a 'held-up' wing phenotype and show poor flight performance.
Mutants show a degenerative phenotype in the indirect flight muscles; at 96 hours after puparium formation, the morphology of the indirect flight muscles and their mitochondria is indistinguishable from wild type, however, by 1-2 days after eclosion, muscle degeneration and fragmentation of the mitochondrial cristae is detectable. 14 day old mutant adults have disorganised muscle fibres which contain prominent vacuoles, and the mitochondria in the muscles have fragmented cristae, with some mitochondria appearing nearly hollow.
The number of dopaminergic neurons in each of the major clusters of the brain (including the dorsomedial, dorsolateral 1 and 2 and posteriomedial clusters) is normal in mutant adults at 3 days after eclosion.
Pink1unspecified has mitochondrion phenotype, suppressible by Drp1+t9.4
Pink1unspecified has mitochondrion phenotype, suppressible by opa1-like[+]/Opa1unspecified
Pink1unspecified has mitochondrion phenotype, non-suppressible by PmiUbi.PR
opa1-likeunspecified/+ or the expression of Drp1+t9.4 abolishes the hyperfusion phenotype of Pink1unspecified mitochondria.
Expression of PmiUbi.PR has no effect on the hyperfusion phenotype of Pink1unspecified mitochondria.
parkunspecified Pink1unspecified double mutants show mitochondrial and muscle degeneration phenotypes in the indirect flight muscles that are identical to those phenotypes seen in either single mutant.
Pink1unspecified is rescued by Pink1+tCa
Pink1unspecified is rescued by Pink1Tag:MYC
Pink1unspecified is rescued by Pink1βTub85D.PC
